Orientational changes and impaired internalization of ellipsoidal nanoparticles by vesicle membranes
Orientational changes and impaired internalization of ellipsoidal nanoparticles by vesicle membranes
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DOI：
10.1039/c3sm50885d
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发表时间：
2013-01-01
期刊：
影响因子：
3.4
通讯作者：
Bahrami, Amir Houshang
中科院分区：
文献类型：
--
作者：
Bahrami, Amir Houshang
生物膜对纳米颗粒的包裹和内化在药物输送应用和纳米医学中发挥着关键作用。我们通过最小化弯曲和粘附能来研究囊泡膜围绕球形和椭圆形纳米颗粒的包裹过程。我们报告了由能量势垒分隔的两种不同的扩散和内化机制，并将内化的成功或失败与颗粒形状和包裹方向联系起来。我们预测具有较高纵横比的椭圆体颗粒的内化更加困难。椭圆体颗粒的包裹与颗粒的方向变化相关。虽然铺展从椭圆体颗粒的平坦侧开始，但颗粒在包裹过程中改变其方向，并且在长长和扁圆椭圆体颗粒的尖端方向上实现内化。
Wrapping and internalization of nanoparticles by biomembranes play a critical role in drug delivery applications and nanomedicine. We study the wrapping process of a vesicle membrane around spherical and ellipsoidal nanoparticles via minimization of the bending and adhesion energies. We report two distinct regimes of spreading and internalization separated by an energy barrier and relate the success or failure of the internalization to the particle shape and wrapping orientation. We predict more difficult internalization for ellipsoidal particles with higher aspect ratios. Wrapping of ellipsoidal particles is associated with an orientational change of the particle. While the spreading starts on the flat side of the ellipsoidal particle, the particle changes its orientation during wrapping and the internalization is achieved in the tip orientation of both prolate and oblate ellipsoidal particles.