Neuroprotection of Early Locomotor Exercise Poststroke: Evidence From Animal Studies.
Neuroprotection of Early Locomotor Exercise Poststroke: Evidence From Animal Studies.
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中风后早期运动锻炼的神经保护：来自动物研究的证据。
DOI：
10.1017/cjn.2015.39
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发表时间：
2015
影响因子：
3
通讯作者：
Xu Ce
中科院分区：
文献类型：
--
作者：
Zhang Pengyue;Xianglei Jia;Hongbo Yang;Zhang Jichuan;Xu Ce
近年来，卒中后早期运动训练在临床和动物研究中引起了广泛关注。一系列动物实验表明，早期运动可通过促进血管生成、抑制急性炎症反应、抑制神经元凋亡、保护血脑屏障等途径，对缺血性脑损伤起到保护作用，改善功能预后。然而，到目前为止，早期自主运动的临床应用是有限的，因为一些临床医生对其有效性缺乏信心。现就脑卒中后早期运动训练的动物模型研究进展作一综述。我们希望对脑卒中后早期运动的全面认识有助于在缺血性脑卒中的治疗中更恰当地实施早期运动。
Early locomotor exercise after stroke has attracted a great deal of attention in clinical and animal research in recent years. A series of animal studies showed that early locomotor exercise poststroke could protect against ischemic brain injury and improve functional outcomes through the promotion of angiogenesis, inhibition of acute inflammatory response and neuron apoptosis, and protection of the blood-brain barrier. However, to date, the clinical application of early locomotor exercise poststroke was limited because some clinicians have little confidence in its effectiveness. Here we review the current progress of early locomotor exercise poststroke in animal models. We hope that a comprehensive awareness of the early locomotor exercise poststroke may help to implement early locomotor exercise more appropriately in treatment for ischemic stroke.