Influence of calmodulin antagonist (stelazine) on agonist-induced calcium mobilization and platelet activation.
Influence of calmodulin antagonist (stelazine) on agonist-induced calcium mobilization and platelet activation.
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钙调蛋白拮抗剂（司特拉嗪）对激动剂诱导的钙动员和血小板活化的影响。
DOI：
10.1016/0006-291x(87)90942-9
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发表时间：
1987
影响因子：
3.1
通讯作者：
Rao,GH
中科院分区：
文献类型：
--
作者：
Rao,GH
高浓度的吩噻嗪可抑制血小板聚集和颗粒内容物的分泌。在这项研究中，我们评估了司他嗪在低浓度时对血小板功能的影响。单用司他嗪对静息状态下的血小板钙水平没有影响，但促进了激动剂诱导的胞浆钙升高。低浓度司他嗪(10μM)和亚阈值浓度凝血酶(0.0 5μ/ml)刺激的血小板不可逆地聚集并释放大量的三磷酸腺苷。这些研究的结果表明，钙调蛋白拮抗剂司他嗪在血小板激活中发挥了新的作用。
Phenothiazines at high concentrations inhibit platelet aggregation and the secretion of granule contents. In this study we have evaluated the influence of stelazine on platelet function at low concentrations. Stelazine alone had no influence on resting calcium levels in platelets but facilitated agonist-induced elevation of cytosolic calcium. Platelets combined with low concentrations of stelazine (10 μM) and stimulated with subthreshold concentrations of thrombin (0.05 μ/ml) aggregated irreversibly and released significant quantitites of ATP. Results of these studies suggest a new role for the calmodulin antagonist stelazine in platelet activation.