Effect of a paraneoplastic cerebellar degeneration-associated neural protein on B-myb promoter activity
Effect of a paraneoplastic cerebellar degeneration-associated neural protein on B-myb promoter activity
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DOI：
10.1016/j.nbd.2003.11.003
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发表时间：
2004-04-01
影响因子：
6.1
通讯作者：
Hirose, G
中科院分区：
文献类型：
--
作者：
Sakai, K;Kitagawa, Y;Hirose, G
在这项研究中，我们已经表明，副肿瘤小脑变性（PCD）相关抗原，pcd 17，结合到细胞周期相关蛋白，MRG 15。MRG 15去抑制E2 F应答性B-myb启动子。pcd 17抗原抑制MRG 15对B-myb转录活性的去抑制，结果，pcd 17抑制启动子。将抗浦肯野细胞抗体（抗Yo）递送到细胞中抑制pcd 17对B-myb启动子活性的抑制。由于B-myb启动子的去抑制与神经元死亡有关，因此结果表明抗体在PCD发病机制中可能起作用。(C)2004年爱思唯尔公司All rights reserved.
In this study, we have shown that a paraneoplastic cerebellar degeneration (PCD)-associated antigen, pcd17, binds to a cell cycle-related protein, MRG15. MRG15 derepresses the E2F-responsive B-myb promoter. The pcd17 antigen inhibits the derepression of the B-myb transcriptional activity by MRG15, and, as a result, pcd17 represses the promoter. Delivery of anti-Purkinje cell antibodies (anti-Yo) into the cells inhibits the repression of B-myb promoter activity by pcd17. Because derepression of the B-myb promoter has been implicated in neuronal death, the results suggest the possible role of the antibodies in the pathogenesis of PCD. (C) 2004 Elsevier Inc. All rights reserved.