Cigarette Smoking-Mediated Macrophage Reprogramming: Mechanistic Insights and Therapeutic Implications.
Cigarette Smoking-Mediated Macrophage Reprogramming: Mechanistic Insights and Therapeutic Implications.
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发表时间：
2018-12
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通讯作者：
David C. Yang;Ching-Hsien Chen
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作者：
David C. Yang;Ching-Hsien Chen
巨噬细胞是单核细胞的成熟形式，在组织稳态和免疫中起着重要作用。在对环境线索的反应中，它们可以经历经典或替代激活，极化成专门的功能子集。病理环境的一个共同标志是吸烟。虽然香烟烟雾对各种细胞过程的贡献已被广泛研究，但其在巨噬细胞极化中的作用一直相互矛盾。本文综述了香烟烟雾暴露的巨噬细胞在促炎和抗炎状态之间的分子和功能差异。我们还强调了与吸烟相关的靶向信号分子调节巨噬细胞可塑性和极化激活的治疗潜力的最新进展。
Macrophages, the mature form of the monocytes, play a significant role in tissue homeostasis and immunity. In response to environmental cues, they can undergo classical or alternative activation, polarizing into specialized functional subsets. A common hallmark of the pathologic environment is represented by cigarette smoking. Although the contribution of cigarette smoke to various cellular processes has been extensively studied, its roles in macrophage polarization have been conflicting. This review discusses the molecular and functional differences of cigarette smoke-exposed macrophages that exist between pro-inflammatory and anti-inflammatory states. We also highlight the most recent advances in therapeutic potential of targeting signaling molecules associated with smoking to modulate macrophage plasticity and polarized activation.