Coated-platelets are higher in amnestic versus nonamnestic patients with mild cognitive impairment.
Coated-platelets are higher in amnestic versus nonamnestic patients with mild cognitive impairment.
复制标题
患有轻度认知障碍的遗忘患者与非遗忘患者相比，涂层血小板更高。
DOI：
10.1097/wad.0b013e31811ec11f
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发表时间：
2007
影响因子：
2.1
通讯作者：
Dale,GeorgeL
中科院分区：
文献类型：
--
作者：
Prodan,CalinI;Ross,ElliottD;Vincent,AndreaS;Dale,GeorgeL
包被血小板是通过与胶原和凝血酶共活化产生的血小板的子集，其表面保留完整的淀粉样前体蛋白。我们分析了66名轻度认知障碍患者（36名健忘症患者和30名非健忘症患者）的血液样本，以检测包被血小板的产生。与非遗忘患者相比，遗忘患者的包被血小板水平显著较高（P= 0.037）。这些发现支持了这样的假设，即包被血小板可能与阿尔茨海默病中发生的淀粉样前体蛋白代谢的必要改变有关。
Coated-platelets, a subset of platelets produced by coactivation with both collagen and thrombin, retain intact amyloid precursor protein on their surface. We analyzed blood samples from 66 individuals with mild cognitive impairment (36 amnestic and 30 nonamnestic) for coated-platelet production. Coated-platelet levels were significantly higher in amnestic compared with nonamnestic patients (P= 0.037). These findings support the hypothesis that coated-platelets may be linked to the requisite alteration in amyloid precursor protein metabolism that occurs in Alzheimer disease.