Amphetamine effects in microtine rodents: A comparative study using monogamous and promiscuous vole species
Amphetamine effects in microtine rodents: A comparative study using monogamous and promiscuous vole species
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DOI：
10.1016/j.neuroscience.2007.07.011
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发表时间：
2007-09-21
期刊：
影响因子：
3.3
通讯作者：
Wang, Z.
中科院分区：
文献类型：
--
作者：
Curtis, J. T.;Wang, Z.
我们比较了苯丙胺诱导的田鼠伏核中多巴胺的释放，这些田鼠表现出不同的交配系统，以检查社会组织和药物滥用之间的潜在相互作用。我们发现基础细胞外多巴胺没有物种或区域差异，然而，一夫一妻制的田鼠在安非他明治疗后细胞外多巴胺的增加比杂乱的田鼠更大、更持久。然后我们检查了安非他明诱导的细胞外多巴胺增加是否可以诱导一夫一妻制田鼠的配对关系。我们发现，尽管伏隔核中的多巴胺增加，但给予雄性草原田鼠苯丙胺并不会诱导配对键，除非对动物进行预处理以阻止 D1 受体激活，而已知 D1 受体激活会抑制配对键的形成。这些结果支持了这样的观点：社会依恋和药物滥用具有共同的神经基质。 (C) 2007 国际广播组织。由爱思唯尔有限公司出版。保留所有权利。
We compared amphetamine-induced dopamine release in the nucleus accumbens of vole species that exhibit differing mating systems to examine potential interactions between social organization and substance abuse. We found no species or regional differences in basal extracellular dopamine, however, monogamous voles had greater and longer-lasting increases in extracellular dopamine after amphetamine treatment than did promiscuous voles. We then examined whether amphetamine-induced increase in extracellular dopamine could induce pair bonds in monogamous voles. We found that, despite increasing dopamine in the nucleus accumbens, amphetamine administration did not induce pair-bonds in male prairie voles unless the animals were pretreated to preclude D1 receptor activation, which is known to inhibit pair-bond formation. These results support suggestions that social attachment and substance abuse share a common neural substrate. (C) 2007 IBRO. Published by Elsevier Ltd. All rights reserved.