Forced transport of deformable containers through narrow constrictions.
Forced transport of deformable containers through narrow constrictions.
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DOI：
10.1103/physreve.90.033006
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发表时间：
2014-05
期刊：
影响因子：
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通讯作者：
R. Kusters;Thijs W. G. van der Heijden;B. Kaoui;J. Harting;C. Storm
中科院分区：
文献类型：
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作者：
R. Kusters;Thijs W. G. van der Heijden;B. Kaoui;J. Harting;C. Storm
我们研究，数值和分析，变形容器的强制运输通过一个狭窄的收缩。我们的中心目标是量化收缩几何形状和主动强迫之间的竞争，调节容器是否可以通过收缩以及以何种速度通过收缩，以及在何种条件下卡住。我们特别关注推动容器的力和通道半径之间的相互关系，因为这些是可以在人工和生理环境中直接控制的外部变量。我们提出的晶格玻尔兹曼模拟，详细阐述了易位的各个阶段，并提出了简化的分析模型，处理两种限制类型的这些膜容器：变形能占主导地位的弯曲或拉伸的贡献。在这两种情况下，我们发现与完整的模拟非常一致，我们的结果表明，不仅半径，而且收缩的长度决定了容器是否会通过。
We study, numerically and analytically, the forced transport of deformable containers through a narrow constriction. Our central aim is to quantify the competition between the constriction geometry and the active forcing, regulating whether and at which speed a container may pass through the constriction and under what conditions it gets stuck. We focus, in particular, on the interrelation between the force that propels the container and the radius of the channel, as these are the external variables that may be directly controlled in both artificial and physiological settings. We present lattice Boltzmann simulations that elucidate in detail the various phases of translocation and present simplified analytical models that treat two limiting types of these membrane containers: deformational energy dominated by the bending or stretching contribution. In either case we find excellent agreement with the full simulations, and our results reveal that not only the radius but also the length of the constriction determines whether or not the container will pass.