Malignant (fibrous) histiocytoma of bone‐fact or fancy?
Malignant (fibrous) histiocytoma of bone‐fact or fancy?
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骨性恶性（纤维性）组织细胞瘤是事实还是幻想？
DOI：
10.1002/1097-0142(197704)39:4
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发表时间：
1977
期刊：
影响因子：
6.2
通讯作者：
T. Matsuno
中科院分区：
文献类型：
--
作者：
D. Dahlin;K. Unni;T. Matsuno
恶性（纤维）组织细胞瘤目前被定义为一种恶性原发性骨肿瘤，包含纤维化细胞和组织学相似但似乎是组织细胞的细胞的混合物。在这种类型的组织细胞瘤中，细胞核常呈锯齿状，胞浆丰富，可呈轻微泡沫状，核仁常较大，多核恶性细胞常为显著特征。许多去分化的软骨肉瘤、骨肉瘤和骨纤维肉瘤含有类似我们认为的恶性（纤维）组织细胞瘤的区域。当恶性骨肿瘤的整体符合所概述的组织学模式时，恶性（纤维性）组织细胞瘤的名称似乎是合适的。在我们的158例骨纤维肉瘤和962例骨肉瘤中，35例肿瘤被分离出来，因为它们似乎被正确地指定为恶性（纤维）组织细胞瘤。受影响的患者年龄范围很广，各种各样的骨骼都有这些肿瘤。大约三分之一的符合5年随访条件的患者是长期无症状的存活者。4例死亡发生在5年后，1例患者在截肢后7年有肺转移的放射学证据。放射治疗至少在两个病例中是有效的。根据目前的知识，这些肿瘤的正确名称是恶性肿瘤，与恶性（纤维）组织细胞瘤一致。
Malignant (fibrous) histiocytoma is currently defined as a malignant primary bone tumor that contains a mixture of fibrogenic cells and cells that are histologically similar but which appear to be histiocytic. In this type of histiocytoma the nuclei are often indented; cytoplasm is usually abundant and may be slightly foamy; nucleoli are often large; and multinucleated malignant cells are usually a prominent feature. Many dedifferentiated chondrosarcomas, osteosarcomas, and fibrosarcomas of bone contain areas that resemble what we regard as malignant (fibrous) histiocytoma. When the entirety of a malignant tumor of bone fits the outlined histologic pattern, the designation of malignant (fibrous) histiocytoma seems appropriate. From 158 fibrosarcomas of bone and 962 osteosarcomas of bone in our files, 35 tumors were segregated because they appeared to be properly designated as malignant (fibrous) histiocytoma. A wide age range was represented by affected patients, and a large variety of bones harbored these tumors. Approximately one‐third of patients eligible for 5‐year follow‐up were long‐term, symptom‐free survivors. Four deaths occurred from the tumor after more than 5 years, and one patient had radiographic evidence of pulmonary metastasis 7 years after amputation. Radiation therapy has been curative in at least two cases. The correct designation for these tumors in the light of current knowledge is malignant tumor, consistent with malignant (fibrous) histiocytoma.