Viscoelasticity of Poly(ethylene glycol) Solutions on Supported Lipid Bilayers via Quartz Crystal Microbalance with Dissipation
Viscoelasticity of Poly(ethylene glycol) Solutions on Supported Lipid Bilayers via Quartz Crystal Microbalance with Dissipation
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DOI：
10.1021/acs.macromol.5b00095
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发表时间：
2015-03
期刊：
影响因子：
5.5
通讯作者：
Ziliang Zhao;Xiangling Ji;R. Dimova;R. Lipowsky;Yonggang Liu
中科院分区：
文献类型：
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作者：
Ziliang Zhao;Xiangling Ji;R. Dimova;R. Lipowsky;Yonggang Liu
在氧化硅基底上形成了1，2-二油酰-sn-甘油-3-磷酸胆碱的支撑脂质双分子层，随后用石英晶体微天平和耗散监测研究了双分子层上聚乙二醇（PEG）溶液的粘弹性。在各种浓度的PEG分子量的宽范围内，没有发现可检测到的吸附的PEG分子的双层。从与共振器支持的脂质双层接触的聚合物溶液的共振频率和能量耗散因子的偏移获得PEG溶液的粘弹性。所得到的聚乙二醇溶液的粘弹性被认为是在良好的溶剂中的线性聚合物链的Zimm模型非常一致。PEG在水中的排除体积标度指数ν显示出随着分子量增加的理想到真实的交叉。指数对于短链采用0.50的值，并且对于长链逐渐增加到0.565。PEG在水（一种良溶剂）中的排斥体积效应的开始存在于4000至8000的分子量范围内。
Supported lipid bilayers of 1,2-dioleoyl-sn- glycero-3-phosphocholine were formed on a silicon oxide substrate, and the viscoelasticity of poly(ethylene glycol) (PEG) solutions above the bilayer was subsequently studied by quartz crystal microbalance with dissipation monitoring. No detectable adsorption of PEG molecules to the bilayer was found over a broad range of PEG molecular weight at various concentrations. The viscoelastic properties of the PEG solutions were obtained from the shifts in the resonance frequency and the energy dissipation factor of the polymer solution in contact with the resonator-supported lipid bilayer. The resulting viscoelastic properties of PEG solutions were found to be in excellent agreement with the Zimm model for linear polymer chains in a good solvent. The excluded volume scaling exponent ν for PEG in water shows an ideal-to-real crossover with increasing molecular weight. The exponent adopts a value of 0.50 for short chains and gradually increases to 0.565 for long chains. The onset of the excluded volume effect of PEG in water, a good solvent, lies in the molecular weight range between 4000 and 8000.