Once-weekly intraocular injections of ganciclovir for maintenance therapy of cytomegalovirus retinitis: Clinical and ocular outcome
Once-weekly intraocular injections of ganciclovir for maintenance therapy of cytomegalovirus retinitis: Clinical and ocular outcome
复制标题
DOI：
10.1093/infdis/174.2.393
复制
发表时间：
1996-08-01
影响因子：
6.4
通讯作者：
Deschenes, J
中科院分区：
文献类型：
--
作者：
Hodge, WG;Lalonde, RG;Deschenes, J
对40例57眼原发性巨细胞病毒（CMV）视网膜炎的临床过程和治疗结果进行了研究。所有患者均接受了为期14天的静脉更昔洛韦治疗，且均无其他终末器官巨细胞病毒疾病。所有受影响的眼睛每周接受400 μ g更昔洛韦玻璃体内注射以维持治疗。患者的中位生存期至少为13个月。15例患者在观察期内发生了19例新的机会性感染，但没有发生新的非眼部巨细胞病毒疾病。在接受维持治疗期间，活动性视网膜炎复发的发生率为68.4%，平均进展时间为14.7周。CMV视网膜炎发生在30.4%以前未受累的眼睛（随访，3.1年）。细菌性眼内炎合并治疗1眼，并发视网膜脱离5眼。因此，每周眼内注射更昔洛韦长期治疗巨细胞病毒性视网膜炎与全身注射更昔洛韦的生存率和眼部预后相似。
The clinical course and the outcome of treatment were studied in 40 patients with primary cytomegalovirus (CMV) retinitis in 57 eyes. All had received one 14-day course of intravenous ganciclovir and all were free of other end-organ CMV disease. All afflicted eyes received weekly intravitreal injections of 400 mu g of ganciclovir for maintenance therapy. Median survival of patients was at least 13 months. Fifteen patients had 19 new opportunistic infections during the observation period, but none developed new nonocular CMV disease. Active retinitis recurred in 68.4% of the eyes while receiving maintenance therapy, with a median time to progression of 14.7 weeks. CMV retinitis occurred in 30.4% of the previously uninvolved eyes (follow-up, 3.1 years). Bacterial endophthalmitis complicated treatment in 1 eye, and 5 eyes developed a retinal detachment. Thus, the long-term treatment of CMV retinitis with weekly intraocular injections of ganciclovir was associated with survival and ocular outcome similar to those reported with systemic ganciclovir.