An Official American Thoracic Society Research Statement: Impact of Mild Obstructive Sleep Apnea in Adults
An Official American Thoracic Society Research Statement: Impact of Mild Obstructive Sleep Apnea in Adults
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DOI：
10.1164/rccm.201602-0361st
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发表时间：
2016-05-01
影响因子：
24.7
通讯作者：
Slyman, Alison
中科院分区：
文献类型：
--
作者：
Chowdhuri, Susmita;Quan, Stuart F.;Slyman, Alison
背景资料：轻度阻塞性睡眠呼吸暂停（OSA）是一种在成人中非常普遍的疾病;然而，轻度OSA是否具有显著的神经认知和心血管并发症尚不确定。目的：本研究声明的具体目标是评估长期不良神经认知和心血管结局是否可归因于成人轻度OSA的证据，评估轻度OSA的治疗是否能有效预防或减少这些不良的神经认知和心血管结局，描述关键的研究空白，并为未来的研究议程提供方向。方法：使用成人OSA的医学主题词和文本词以及手动检索，从多个参考数据库中进行文献检索。务实的系统评价的相关机构的证据performed.Results：研究是不一致的，在他们的定义“轻度”阻塞性睡眠呼吸暂停综合征。关于轻度阻塞性睡眠呼吸暂停与日间嗜睡之间的关系，数据并不一致。然而，轻度OSA的治疗可以改善基线时嗜睡的患者的嗜睡，并改善生活质量。有有限的或不一致的证据有关的影响轻度OSA的治疗对神经认知，情绪，交通工具事故，心血管事件，中风，和arrhythmia.Conclusions：有证据表明，治疗轻度OSA的个人谁表现出主观嗜睡可能是有益的。治疗还可以改善生活质量。未来的研究议程应集中于阐明轻度OSA的影响以及有效治疗对其他神经认知和心血管终点的影响，如文件中所详述。
Background: Mild obstructive sleep apnea (OSA) is a highly prevalent disorder in adults; however, whether mild OSA has significant neurocognitive and cardiovascular complications is uncertain.Objectives: The specific goals of this Research Statement are to appraise the evidence regarding whether long-term adverse neurocognitive and cardiovascular outcomes are attributable to mild OSA in adults, evaluate whether or not treatment of mild OSA is effective at preventing or reducing these adverse neurocognitive and cardiovascular outcomes, delineate the key research gaps, and provide direction for future research agendas.Methods: Literature searches from multiple reference databases were performed using medical subject headings and text words for OSA in adults as well as by hand searches. Pragmatic systematic reviews of the relevant body of evidence were performed.Results: Studies were incongruent in their definitions of "mild" OSA. Data were inconsistent regarding the relationship between mild OSA and daytime sleepiness. However, treatment of mild OSA may improve sleepiness in patients who are sleepy at baseline and improve quality of life. There is limited or inconsistent evidence pertaining to the impact of therapy of mild OSA on neurocognition, mood, vehicle accidents, cardiovascular events, stroke, and arrhythmias.Conclusions: There is evidence that treatment of mild OSA in individuals who demonstrate subjective sleepiness may be beneficial. Treatment may also improve quality of life. Future research agendas should focus on clarifying the effect of mild OSA and impact of effective treatment on other neurocognitive and cardiovascular endpoints as detailed in the document.