Cognitive-Behavioral Therapy Versus Transcranial Direct Current Stimulation for Augmenting Selective Serotonin Reuptake Inhibitors in Obsessive-Compulsive Disorder Patients
Cognitive-Behavioral Therapy Versus Transcranial Direct Current Stimulation for Augmenting Selective Serotonin Reuptake Inhibitors in Obsessive-Compulsive Disorder Patients
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DOI：
10.32598/bcn.11.1.13333.2
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发表时间：
2020-01-01
影响因子：
1.7
通讯作者：
Morsali, Yousef
中科院分区：
文献类型：
--
作者：
Dadashi, Mohsen;Asl, Vida Yousefi;Morsali, Yousef
简介：强迫症（OCD）属于精神疾病的范畴，如果不接受必要的治疗，有可能变成一种慢性疾病。强迫症的主要特征是频繁或强烈的困扰和强迫，可能会给患者带来巨大的痛苦和痛苦。此外，作为最普遍的异常之一，抑郁症通常伴随着强迫症。本研究旨在比较暴露与反应预防（ERP）和经颅直流电刺激（tDCS）治疗辅助药物治疗对减轻强迫症患者强迫抑郁症状严重程度和改善生活质量的影响。方法：本研究为准实验研究，采用前测、后测和随访设计。统计人群包括伊朗赞詹省所有被诊断为强迫症的患者。采用目的抽样法，选取赞詹Shahid Beheshti医疗中心的强迫症患者26例。然后，他们被随机分配到两个治疗组。研究对象在治疗前、治疗后、治疗后1个月和治疗后2个月分别完成了耶鲁布朗强迫症量表（Y-BOCS）、贝克抑郁量表- ii （BDI 2）和生活质量问卷。采用协方差分析（ANCOVA）和可靠变化指数（RCI）方法分别衡量统计学意义和临床意义。收集的数据采用SPSS进行分析。结果：ERP组与tDCS组在测试后阶段强迫症和抑郁症状方面差异无统计学意义（P < 0.05）。相反，在生活质量方面，ERP组和tDCS组在测试后阶段有显著差异(P
Introduction: Obsessive-Compulsive Disorder (OCD) belongs to the categories of psychiatric disorders with the potential to turn into a chronic condition without receiving the necessary treatments. The main feature of OCD is the frequent or intense obsession and compulsion that might induce great pain and suffering in patients. Moreover, as one of the most prevalent abnormalities, depression usually follows OCD. The present study aimed to compare the effects of Exposure and Response Prevention (ERP) and Transcranial Direct Current Stimulation (tDCS) treatments adjunct to pharmacotherapy on decreasing the severity of obsession-depression symptoms and improving the quality of life in OCD patients.Methods: This was a quasi-experimental study with a pre-test, post-test design and a follow-up stage. The statistical population comprised all the patients diagnosed with OCD in Zanjan Province, Iran. Besides, 26 OCD patients referring to Shahid Beheshti Medical Center in Zanjan were selected using a purposive sampling method. Then, they were randomly assigned to two treatment groups. The study subjects completed the Yale Brown Obsessive-Compulsive Scale (Y-BOCS), Beck Depression Inventory-II (BDI 2), and the Quality of Life Questionnaire at the pre-treatment, post-treatment, and follow-up stages (1 month and 2 months after the treatment). Analysis of Covariance (ANCOVA) and Reliable Change Index (RCI) methods were used to measure statistical and clinical significances, respectively. The collected data were analyzed using SPSS.Results: The obtained data suggested no significant difference between the ERP and tDCS groups concerning the symptoms of OCD and depression at the post-test stage (P>0.05). Conversely, in terms of life quality, there was a significant difference between the ERP and tDCS groups at the post-test phase (P