Breakpoint identification and smoothing of array comparative genomic hybridization data
Breakpoint identification and smoothing of array comparative genomic hybridization data
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DOI：
10.1093/bioinformatics/bth355
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发表时间：
2004-12-12
期刊：
影响因子：
5.8
通讯作者：
Ylstra, B
中科院分区：
文献类型：
--
作者：
Jong, K;Marchiori, E;Ylstra, B
我们描述了一种工具，称为aCGH平滑，用于自动识别断点和平滑微阵列比较基因组杂交（阵列CGH）数据。aCGH-Smooth是用Visual C++编写的，具有用户友好的界面，包括可视化的结果和用户自定义的参数，以适应数据平滑和断点识别的性能。aCGH-Smooth可以处理所有阵列CGH平台生成的阵列CGH数据：BAC、PAC、粘粒、cDNA和寡核苷酸CGH阵列。该工具已成功应用于实际数据。
We describe a tool, called aCGH-Smooth, for the automated identification of breakpoints and smoothing of microarray comparative genomic hybridization (array CGH) data. aCGH-Smooth is written in visual C++, has a user-friendly interface including a visualization of the results and user-defined parameters adapting the performance of data smoothing and breakpoint recognition. aCGH-Smooth can handle array-CGH data generated by all array-CGH platforms: BAC, PAC, cosmid, cDNA and oligo CGH arrays. The tool has been successfully applied to real-life data.