Highly accurate Debye models for normal and malignant breast tissue dielectric properties at microwave frequencies
Highly accurate Debye models for normal and malignant breast tissue dielectric properties at microwave frequencies
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DOI：
10.1109/lmwc.2007.910465
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发表时间：
2007-12-01
影响因子：
3
通讯作者：
Hagness, Susan C.
中科院分区：
文献类型：
--
作者：
Lazebnik, Mariya;Okoniewski, Michal;Hagness, Susan C.
时域有限差分（FDTD）方法被广泛用作新兴的微波乳腺癌检测和治疗技术的开发、验证和优化的计算工具。当表示的德拜参数，色散乳腺组织的介电性能可以有效地纳入FDTD代码。以前，我们的实验特点是从0.5到20 GHz的大量切除的正常和恶性乳腺组织样本的介电特性。我们根据特定样本中脂肪组织的百分比将正常组织数据的大型数据库细分为三组。此外，我们形成了一组包含至少30%恶性组织的所有癌症样本。我们使用单极Cole-Cole模型总结了数据，该模型严格拟合三个正常组织组和一个恶性组织组的中值介电特性。在这封信中，我们提出了计算简单的单极和双极德拜模型，保留了高精度的科尔-科尔模型。模型参数推导出两组频率范围：从0.5到20 GHz的整个测量频率范围，和3.1-10.6 GHz的FCC频段分配给超宽带医疗应用。拟议的德拜模型提供了一种方法，用于创建计算效率高的FDTD乳腺模型与现实的宽带介电特性来自最大和最全面的实验研究，迄今为止对人类乳腺组织。
The finite difference time domain (FDTD) method is widely used as a computational tool for development, validation, and optimization of emerging microwave breast cancer detection and treatment techniques. When expressed in terms of Debye parameters, dispersive breast tissue dielectric properties can be efficiently incorporated into FDTD codes. Previously, we experimentally characterized the dielectric properties of a large number of excised normal and malignant breast tissue samples from 0.5 to 20 GHz. We subdivided the large database of normal tissue data into three groups based on the percent adipose tissue present in a particular sample. In addition, we formed a group of all cancer samples that contained at least 30% malignant tissue. We summarized the data using one-pole Cole-Cole models that were rigorously fit to the median dielectric properties of the three normal tissue groups and one malignant tissue group. In this letter, we present computationally simpler one- and two-pole Debye models that retain the high accuracy of the Cole-Cole models. Model parameters are derived for two sets of frequency ranges: the entire measurement frequency range from 0.5 to 20 GHz, and the 3.1-10.6 GHz FCC band allocated for ultrawide-band medical applications. The proposed Debye models provide a means for creating computationally efficient FDTD breast models with realistic wideband dielectric properties derived from the largest and most comprehensive experimental study conducted to date on human breast tissue.