The genetics of human systemic lupus erythematosus.
The genetics of human systemic lupus erythematosus.
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人类系统性红斑狼疮的遗传学。
DOI：
10.1016/j.it.2003.09.006
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发表时间：
2003
影响因子：
16.8
通讯作者：
Tsao,BettyP
中科院分区：
文献类型：
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作者：
Tsao,BettyP
在过去的十年里，人类系统性红斑狼疮 (SLE) 的基因解剖一直处于深入研究之中。尽管多基因、多因素疾病固有的复杂性具有挑战性，但在过去几年中，通过对包含 SLE 患者的家庭的连锁和关联研究以及人群的病例对照研究，已经获得了一些新的见解。此外，我们对人类基因组和新兴技术的理解的最新进展为分析复杂性状（例如系统性红斑狼疮）提供了新工具。本文概述了我们目前对 SLE 遗传基础的理解，并简要回顾了连锁和关联研究的结果。
Genetic dissection of human systemic lupus erythematosus (SLE) has been under intense studies during the past decade. Although the complexity inherent to polygenic, multifactorial diseases is challenging, several new insights have been obtained in the past several years using linkage and association studies of families containing SLE patients as well as case-control studies of populations. In addition, recent advances in our understanding of the human genome and emerging technology have been providing new tools in analyses of complex traits, such as SLE. An overview of our current understanding of the genetic basis of SLE and a brief review of findings of linkage and association studies are described here.