[Interaction of glucocorticoids and the Sonic Hedgehog pathway during brain development].
[Interaction of glucocorticoids and the Sonic Hedgehog pathway during brain development].
复制标题
[大脑发育过程中糖皮质激素与 Sonic Hedgehog 通路的相互作用]。
DOI：
10.1051/medsci/2009258-9713
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
P. Gressens
中科院分区：
文献类型：
--
作者：
O. Baud;P. Gressens
在过去的20-30年里，皮质类固醇一直被用于预防与早产有关的肺部和脑部疾病的致命后果。然而，许多数据表明风险受益比较低，并且RMN研究客观化了不良神经发育结局的长期出现。虽然已经提出了多种机制来解释GCs对大脑发育的影响，但到目前为止还没有明确的机制。最近发表了一项突破性的研究，确定了音刺猬（Shh）信号通路作为Gcs作用的靶点。Shh是大脑发育和神经干/祖细胞的重要调节因子，GCs抑制Shh诱导的小脑祖细胞增殖; Shh通过诱导酶11 β HSD 2发挥作用，该酶使GCs皮质酮和泼尼松龙失活，而不是地塞米松。这些数据应该导致开发新的分子（GC或Shh激动剂），既有效又有神经保护作用。
Corticosteroids have been used for the past 20-30 years to prevent lethal consequences of pulmonary and cerebral disorders linked to prematurity. However, many data suggest a low risk-benefit ratio, and the long-term emergence of adverse neurodevelopmental outcomes objectivated by RMN studies. Although multiple mechanisms have been proposed to explain GCs effects on brain development, none has clearly emerged so far. A breakthrough study has been recently published, which identified the sonic hedgehog (Shh) signaling pathway as the target of Gcs action. Shh is a crucial regulator of brain development and neural stem/progenitor cells, and GCs suppress Shh-induced proliferation of cerebellar progenitor cells ; Shh acts through the induction of the enzyme 11betaHSD2, which inactivates the GCs corticosterone and prednisolone, but not dexamethasone. These data should lead to the development of novel molecules (either GC or Shh agonists) both -efficient and neuroprotective.
影响因子：
158.5
作者：
Stark, AR;Carlo, WA;Stoll, BJ
通讯作者：
Stoll, BJ
影响因子：
9.8
作者：
McEwen, BS
通讯作者：
McEwen, BS