Molecular, structural, and functional characterization of Alzheimer's disease: Evidence for a relationship between default activity, amyloid, and memory
Molecular, structural, and functional characterization of Alzheimer's disease: Evidence for a relationship between default activity, amyloid, and memory
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DOI：
10.1523/jneurosci.2177-05.2005
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发表时间：
2005-08-24
影响因子：
5.3
通讯作者：
Mintun, MA
中科院分区：
文献类型：
--
作者：
Buckner, RL;Snyder, AZ;Mintun, MA
阿尔茨海默病（AD）和与AD相关的前因因素进行了探讨，使用淀粉样蛋白成像和无偏的纵向萎缩的措施，结合重新分析以前的代谢和功能研究。总共，来自764名参与者的数据在五种体内成像方法中进行了比较。在后部皮质区域，包括后扣带、压后和侧顶叶皮质，观察到效应的收敛。这些区域在年轻人的默认状态下是活跃的，并且在患有AD的老年人中也显示淀粉样蛋白沉积。在AD进展的早期阶段，在这些后皮质区域出现明显的萎缩和代谢异常;还观察到内侧颞区萎缩。事件相关功能磁共振成像研究进一步揭示，这些皮层区域在年轻人成功的记忆提取过程中是活跃的。一种可能性是与区域特异性默认活动相关的终生脑代谢使皮质区域易于发生AD相关变化，包括淀粉样蛋白沉积、代谢中断和萎缩。这些皮质区域可能是内侧颞叶网络的一部分，内侧颞叶的破坏会导致记忆障碍。
Alzheimer's disease ( AD) and antecedent factors associated with AD were explored using amyloid imaging and unbiased measures of longitudinal atrophy in combination with reanalysis of previous metabolic and functional studies. In total, data from 764 participants were compared across five in vivo imaging methods. Convergence of effects was seen in posterior cortical regions, including posterior cingulate, retrosplenial, and lateral parietal cortex. These regions were active in default states in young adults and also showed amyloid deposition in older adults with AD. At early stages of AD progression, prominent atrophy and metabolic abnormalities emerged in these posterior cortical regions; atrophy in medial temporal regions was also observed. Event-related functional magnetic resonance imaging studies further revealed that these cortical regions are active during successful memory retrieval in young adults. One possibility is that lifetime cerebral metabolism associated with regionally specific default activity predisposes cortical regions to AD-related changes, including amyloid deposition, metabolic disruption, and atrophy. These cortical regions may be part of a network with the medial temporal lobe whose disruption contributes to memory impairment.