Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk
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DOI：
10.1038/ncomms6303
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发表时间：
2014-10-01
影响因子：
16.6
通讯作者：
Tamimi, Rulla M.
中科院分区：
文献类型：
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作者：
Lindstroem, Sara;Thompson, Deborah J.;Tamimi, Rulla M.
乳腺摄影密度反映了乳腺中与脂肪组织相关的基质和上皮组织的量，并且是乳腺癌的强风险因素。在这里，我们报告了来自全基因组关联研究GWAS的荟萃分析结果，其中包括三种乳腺摄影密度表型：致密区，非致密区和密度百分比，第1阶段多达7，916名女性，第2阶段另有10，379名女性。我们发现全基因组显著（P
Mammographic density reflects the amount of stromal and epithelial tissues in relation to adipose tissue in the breast and is a strong risk factor for breast cancer. Here we report the results from meta-analysis of genome-wide association studies GWAS) of three mammographic density phenotypes: dense area, non-dense area and percent density in up to 7,916 women in stage 1 and an additional 10,379 women in stage 2. We identify genome-wide significant (P