INTERLEUKIN-1 IMMUNOREACTIVE INNERVATION OF THE HUMAN HYPOTHALAMUS
INTERLEUKIN-1 IMMUNOREACTIVE INNERVATION OF THE HUMAN HYPOTHALAMUS
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DOI：
10.1126/science.3258444
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发表时间：
1988-04-15
期刊：
影响因子：
56.9
通讯作者：
SAPER, CB
中科院分区：
文献类型：
--
作者：
BREDER, CD;DINARELLO, CA;SAPER, CB
白细胞介素-1（IL-1）是介导急性期反应的细胞因子。IL-1的许多作用涉及对中枢神经系统的直接作用。然而，IL-1以前没有被确定为脑内的内在成分，除了在神经胶质细胞中。一种针对人IL-1 β的抗血清。用于对人脑进行IL-1 β的化学染色。比如免疫反应神经元IL-1 β-发现免疫反应性纤维支配控制急性期反应的中心成分的关键内分泌和自主细胞群。这些结果表明，IL-1可能是中枢神经系统通路中的一种内在神经调节剂，介导急性期反应的各种代谢功能，包括产生发热反应的体温变化。
Interleukin-1 (IL-1) is a cytokine that mediates the acute phase reaction. Many of the actions of IL-1 involve direct effects on the central nervous system. However, IL-1 has not previously been identified as an intrinsic component within the brain, except in glial cells. An antiserum directed against human IL-1.beta. was used to stain the human brain immunohistochemically for IL-1.beta.-like immunoreactive neural elements. IL-1.beta.-immunoreactive fibers were found innervating the key endocrine and autonomic cell groups that control the central components of the acute phase reaction. These results indicate that IL-1 may be an intrinsic neurmodulator in central nervous system pathways that mediate various metabolic functions of the acute phase reaction, including the body temperature changes that produce the febrile response.