Use of gated 13N-NH3 micro-PET to examine left ventricular function in rats
Use of gated 13N-NH3 micro-PET to examine left ventricular function in rats
复制标题
DOI：
10.1016/j.nucmedbio.2011.12.009
复制
发表时间：
2012-07-01
影响因子：
3.1
通讯作者：
Slart, Riemer H. J. A.
中科院分区：
文献类型：
--
作者：
Szymanski, Mariusz K.;Kruizinga, Silvana;Slart, Riemer H. J. A.
前言：心肌灌注门控技术提供了在临床和临床前试验中测量左心室收缩末期(ESV)、舒张末容量(EDV)和左心室射血分数(LVEF)的可能性。本研究的目的是比较N-13-NH3和F-18-FDG对不同模型大鼠的左心室容量(LVV)和左心室射血分数(LVEF)的影响。方法：对18只雄性Wistar大鼠、12只对照大鼠和6只心肌梗死(MI)大鼠进行了Micro-PET显像。用门控N-13-NH3和F-18-FDG顺序扫描大鼠的左心室容积和左心室射血分数。结果：心肌梗死组和对照组大鼠左心室射血分数分别为45.6+/-8.9和75.3+/-9.4%，平均收缩末容积分别为0.40±-0.12和0.14±-0.11ml，平均收缩末容积分别为0.53+/-16和0.75+/-0.18ml。在计算ESV时，N-13-NH3和F-18-FDG值之间存在中度至良好的相关性[r=0.80，P
Introduction: Myocardial perfusion gating techniques offer the possibility of measurement of left ventricular end-systolic (ESV) and end-diastolic volume (EDV) and left ventricular ejection fraction (LVEF) in clinical and preclinical trials. The aim of this study was to evaluate left ventricular volumes (LVV) and LVEF with N-13-NH3 in comparison with the reference F-18-FDG in different rat models.Methods: In this study, 18 male Wistar rats, 12 control rats and 6 rats with myocardial infarction (MI) were imaged with micro-PET. The rats were scanned with gated N-13-NH3 and F-18-FDG sequentially for the assessment of LVV and LVEF. A validated three-dimensional segmentation algorithm was used to calculate LVV and LVEF.Results: Mean LVEF measured with N-13-NH3 was 45.6+/-8.9 and 75.3+/-9.4%, mean ESV was 0.40+/-0.12 and 0.14+/-0.11 ml, and mean EDV was 0.53+/-16 and 0.75+/-0.18 ml for MI and control rats, respectively. Moderate to good correlations were observed between values of N-13-NH3 and F-18-FDG for calculation of ESV [r=0.80, P