Asymmetrical transport of glucose across the in vitro perfused human placenta
Asymmetrical transport of glucose across the in vitro perfused human placenta
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DOI：
10.1053/plac.2002.0869
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发表时间：
2003-01-01
期刊：
影响因子：
3.8
通讯作者：
Malek, A
中科院分区：
文献类型：
--
作者：
Schneider, H;Reiber, W;Malek, A
采用离体子叶的双重体外灌流法，研究了葡萄糖经胎盘的通量和组织的消耗。测试了从母体到胎儿侧或相反方向的不同经胎盘葡萄糖梯度的影响。在两个方向上，从供体回路的摄取以及经胎盘的流量与两侧之间的葡萄糖浓度差之间存在线性相关性。在可比较的梯度下，与另一方向相比，从母体侧到胎儿侧的梯度的摄取和通量均显著更高。对于D-葡萄糖的不可代谢的2-脱氧-类似物，未观察到通量的不对称性。其由胎盘组织代谢以及与胎盘基底膜相比跨微绒毛的膜转运能力的差异。合胞体滋养层可以解释经胎盘葡萄糖流量的不对称性。(C)2002爱思唯尔科技有限公司。保留所有权利。
The transplacental flux of glucose together with the consumption by the tissue was studied in human term placenta using the dual in vitro perfusion of an isolated cotyledon. The effect of different transplacental glucose gradients going either from the maternal to the foetal side or in the opposite direction was tested. A linear correlation between uptake from the donor circuit as well as transplacental flux and concentration difference of glucose between the two sides was found in both directions. At comparable gradients both uptake and flux were significantly higher with the gradient going from the maternal to the foetal side as compared to the other direction.For the non-metabolizable 2-deoxy-analog of D-glucose no asymmetry of flux was seen.The large fraction of glucose uptake, which is metabolized by placental tissue together with the difference in membrane transport capacity across the microvillous as compared to the basal membrane of the syncytiotrophoblast could be an explanation for the asymmetry in transplacental glucose flux. (C) 2002 Elsevier Science Ltd. All rights reserved.