Regulation of Cell Adhesion and Migration via Microtubule Cytoskeleton Organization, Cell Polarity, and Phosphoinositide Signaling.
Regulation of Cell Adhesion and Migration via Microtubule Cytoskeleton Organization, Cell Polarity, and Phosphoinositide Signaling.
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通过微管细胞骨架组织，细胞极性和磷酸肌醇信号传导调节细胞粘附和迁移。
DOI：
10.3390/biom13101430
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发表时间：
2023-09-22
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
癌细胞转移到远处器官的能力取决于它们执行精心设计的细胞粘附和迁移过程的能力。由于大多数人类癌症是上皮起源的（癌），粘附/紧密连接蛋白（例如，E-钙粘蛋白、紧密连接蛋白和封闭蛋白）与粘附和迁移表型的伴随获得已经被广泛研究。大多数关于细胞粘附和迁移的研究和综述都集中在肌动蛋白细胞骨架及其重组上。然而，转移癌细胞经历其细胞骨架系统的广泛重组，特别是在微管的起源/成核位点及其取向（例如，从非中心体到中心体微管组织中心）。微管的空间和时间重组与转移过程中上皮细胞可逆转化为间充质细胞时粘附和迁移表型的获得功能相关的确切机制仍知之甚少。在这期特刊“细胞粘附和迁移的分子机制”中，我们从微管骨架重组、细胞极性和磷酸肌醇信号传导的角度突出了细胞粘附和迁移。
The capacity for cancer cells to metastasize to distant organs depends on their ability to execute the carefully choreographed processes of cell adhesion and migration. As most human cancers are of epithelial origin (carcinoma), the transcriptional downregulation of adherent/tight junction proteins (e.g., E-cadherin, Claudin and Occludin) with the concomitant gain of adhesive and migratory phenotypes has been extensively studied. Most research and reviews on cell adhesion and migration focus on the actin cytoskeleton and its reorganization. However, metastasizing cancer cells undergo the extensive reorganization of their cytoskeletal system, specifically in originating/nucleation sites of microtubules and their orientation (e.g., from non-centrosomal to centrosomal microtubule organizing centers). The precise mechanisms by which the spatial and temporal reorganization of microtubules are linked functionally with the acquisition of an adhesive and migratory phenotype as epithelial cells reversibly transition into mesenchymal cells during metastasis remains poorly understood. In this Special Issue of “Molecular Mechanisms Underlying Cell Adhesion and Migration”, we highlight cell adhesion and migration from the perspectives of microtubule cytoskeletal reorganization, cell polarity and phosphoinositide signaling.
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影响因子：
19
作者：
Bakir B;Chiarella AM;Pitarresi JR;Rustgi AK
通讯作者：
Rustgi AK
影响因子：
16.6
作者：
Banerjee P;Xiao GY;Tan X;Zheng VJ;Shi L;Rabassedas MNB;Guo HF;Liu X;Yu J;Diao L;Wang J;Russell WK;Roszik J;Creighton CJ;Kurie JM
通讯作者：
Kurie JM
DOI：
10.1083/jcb.200812034
发表时间：
2009-06-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Dupin I;Camand E;Etienne-Manneville S
通讯作者：
Etienne-Manneville S
影响因子：
9.2
作者：
Drabek, Ksenija;van Ham, Marco;Galjart, Niels
通讯作者：
Galjart, Niels
影响因子：
9.7
作者：
Costa, Patricia;Blowes, Liisa M.;Connelly, John T.
通讯作者：
Connelly, John T.