Cell pattern in the Arabidopsis root epidermis determined by lateral inhibition with feedback
Cell pattern in the Arabidopsis root epidermis determined by lateral inhibition with feedback
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DOI：
10.1105/tpc.010434
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发表时间：
2002-03-01
期刊：
影响因子：
11.6
通讯作者：
Schiefelbein, J
中科院分区：
文献类型：
--
作者：
Lee, MM;Schiefelbein, J
在拟南芥的根表皮中，毛细胞和非毛细胞类型以独特的位置依赖性模式被指定。在这里，我们表明 WEREWOLF (WER)、CAPRICE (CPC) 和 GLABRA2 (GL2) 基因之间的转录反馈循环有助于建立这种模式。位置线索偏向 WER MYB 基因的表达，导致位于特定位置 (N) 的细胞中诱导 CPC 和 GL2 并采用非毛发命运。 CPC编码的截短的MYB介导侧向抑制机制，负向调节WER、GL2及其自身在替代位置（H）的基因，从而诱导头发命运。这些结果为理解植物细胞类型模式的确定提供了分子遗传框架。
In the root epidermis of Arabidopsis, hair and nonhair cell types are specified in a distinct position-dependent pattern. Here, we show that transcriptional feedback loops between the WEREWOLF (WER), CAPRICE (CPC), and GLABRA2 (GL2) genes help to establish this pattern. Positional cues bias the expression of the WER MYB gene, leading to the induction of CPC and GL2 in cells located in a particular position (N) and adoption of the nonhair fate. The truncated MYB encoded by CPC mediates a lateral inhibition mechanism to negatively regulate WER, GL2, and its own gene in the alternative position (H) to induce the hair fate. These results provide a molecular genetic framework for understanding the determination of a cell-type pattern in plants.