A heavy particle comparative study. Part II: cell survival versus depth.
A heavy particle comparative study. Part II: cell survival versus depth.
复制标题
重粒子比较研究。
DOI：
10.1259/0007-1285-51-609-704
复制
发表时间：
1978
影响因子：
2.6
通讯作者：
J. Robertson
中科院分区：
文献类型：
--
作者：
M. R. Raju;E. Bain;S. Carpenter;R. A. Cox;J. Robertson
对一系列入射剂量的质子、氦气、碳、氖气、氩气、负介子、中子和 60Co 光子束进行了细胞存活率和穿透深度的测量。使用悬浮在含凝胶介质中的培养人类细胞（T1），发现测量结果对于促进脊形过滤器的设计以在感兴趣的区域产生等效应非常有用。研究发现，重带电粒子束（质子、氦、碳、氖和负π介子）在穿透深度上可产生类似的细胞杀伤作用。由于较高 LET 下的饱和效应，与其他重带电粒子束相比，氩离子在深度杀死充气细胞方面效果较差。与入口处相比，当布拉格峰拓宽至 10 cm 宽度时，单场曝光在感兴趣区域深处的细胞杀伤没有显着差异。然而，当使用两个具有重叠峰的相对场时，在峰区域获得了杀伤力的大幅增强。
Cell-survival measurements with depth of penetration were made for a series of incident doses of proton, helium, carbon, neon, argon, negative pion, neutron, and 60Co photon beams. Cultured human cells (T1) suspended in a gel-containing medium were used, and the measurements were found to be very useful in facilitating the design of ridge filters to produce iso-effects in the region of interest. Heavy charged particle beams (proton, helium, carbon, neon, and negative pion) were found to produce similar cell killing with depth of penetration. Because of saturation effects at higher LET, argon ions were less effective in killing aerated cells at depth, compared with other heavy charged-particle beams. Cell killing at depth in the region of interest, compared with that at the entrance, was not significantly different for single-field exposures when the Bragg peaks were broadened to cover a width of 10 cm. However, when two opposed fields with overlapping peaks were used, a large enhancement in killing was obtained in the peak region.