INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEINS IN THE HUMAN CIRCULATION - A REVIEW
INSULIN-LIKE GROWTH-FACTOR BINDING-PROTEINS IN THE HUMAN CIRCULATION - A REVIEW
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DOI：
10.1159/000184186
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发表时间：
1994-01-01
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影响因子：
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通讯作者：
BAXTER, RC
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作者：
BAXTER, RC
胰岛素样生长因子（IGF）的作用和生物利用度是由6个IGF结合蛋白家族调节的。IGFBP-3是主要的循环IGFBP，其独特之处在于与糖蛋白、酸不稳定亚基（ALS）结合，与IGF-I或IGF-II形成三元复合物。这种三聚体的每个组成部分都依赖于生长激素，循环igf的降糖潜能似乎以这种形式被中和。复合物中的igf具有大大延长的循环半衰期，其稳定性是由于ALS的存在而赋予的，ALS本身在循环中非常稳定。IGFBP-1似乎不是igf的载体，而是作为其代谢活动的急性调节剂。在这种作用下，它可以被视为胰岛素反调节因子，在禁食或低血糖时阻断“游离”胰岛素样活性。IGF-I给药引起循环igfbp的复杂变化，因此，如果要优化IGF-I的治疗潜力，详细了解其调节是必不可少的。
The actions and bioavailability of the insulin-like growth factors (IGFs) are regulated by a family of six IGF binding proteins. IGFBP-3, the major circulating IGFBP, is unique in combining with a glycoprotein, the acid-labile subunit (ALS), to form a ternary complex with IGF-I or IGF-II. Each component of this trimer is growth hormone-dependent, and the hypoglycemic potential of circulating IGFs appears neutralized in this form. IGFs in the complex have a greatly extended circulating half-life, their stability being conferred by the presence of ALS, which is itself very stable in the circulation. IGFBP-1 does not appear to be a carrier of IGFs, but to act as an acute modulator of their metabolic activities. In this role it can be viewed as an insulin counter-regulator, blocking 'free' insulin-like activity during fasting or hypoglycemia. IGF-I administration causes complex changes in circulating IGFBPs, so that a detailed knowledge of their regulation is essential if the therapeutic potential of IGF-I is to be optimised.