The position and function of the Notch-mediated eye growth organizer: the roles of JAK/STAT and four-jointed
The position and function of the Notch-mediated eye growth organizer: the roles of JAK/STAT and four-jointed
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DOI：
10.1038/embor.2009.140
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发表时间：
2009-09-01
期刊：
影响因子：
7.7
通讯作者：
Dominguez, Maria
中科院分区：
文献类型：
--
作者：
Jose Gutierrez-Avino, Francisco;Ferres-Marco, Dolors;Dominguez, Maria
在许多动物系统中，空间受限区域（组织者）中模式信号的局部激活对于促进发育中器官的生长至关重要。然而，组织者是如何建立的以及他们的活动如何影响全球器官的生长仍然知之甚少。在果蝇眼睛中，局部Notch激活建立了一个保守的背腹组织，促进生长。背侧选择器易洛魁复合体定义了组织者在第一龄中期的位置，并且通过其未配对的配体，Janus激酶（JAK）/信号转导器和转录激活剂（STAT）途径被认为介导组织者下游的整体生长。然而，在这里我们表明，未配对的/JAK/STAT 通路实际上是组织者空间控制的基本元素，位于Notch 激活的上游。此外，我们确定了四关节，Fat 和 Hippo 肿瘤抑制途径的目标，作为组织者控制的生长的中介者。这些发现重新定义了组织者形成和功能的过程，他们将四关节确定为调节节点，整合了多种生长控制途径。
In many animal systems, the local activation of patterning signals in spatially confined regions (organizers) is crucial for promoting the growth of developing organs. Nevertheless, how organizers are set up and how their activity influences global organ growth remains poorly understood. In the Drosophila eye, local Notch activation establishes a conserved dorsal-ventral organizer that promotes growth. The dorsal selector Iroquois complex defines the position of the organizer at the mid-first instar, and through its ligand, unpaired, the Janus kinase (JAK)/signal transducers and activator of transcription (STAT) pathway is thought to mediate global growth downstream of the organizer. However, here we show that the unpaired/JAK/STAT pathway is actually a fundamental element in the spatial control of the organizer, upstream from Notch activation. Furthermore, we identify four-jointed, a target of the Fat and Hippo tumour-suppressor pathways, as a mediator of the growth controlled by the organizer. These findings redefine the process of organizer formation and function, and they identify four-jointed as a regulatory node, integrating multiple growth-control pathways.