Perspectives of diverse Spanish- and English-speaking patients on the clinical use of polygenic risk scores.
Perspectives of diverse Spanish- and English-speaking patients on the clinical use of polygenic risk scores.
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DOI：
10.1016/j.gim.2022.03.006
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发表时间：
2022-06
影响因子：
8.8
通讯作者：
Abul-Husn, Noura S.
中科院分区：
文献类型：
--
作者：
Suckiel, Sabrina A.;Braganza, Giovanna T.;Aguiniga, Karla Lopez;Odgis, Jacqueline A.;Bonini, Katherine E.;Kenny, Eimear E.;Hamilton, Jada G.;Abul-Husn, Noura S.
随着多基因风险评分（PRS）成为告知临床护理的有前途的工具，迫切需要以患者为中心的证据来指导其实施，特别是在不同人群中。在这里，我们对不同的西班牙语和英语患者进行了深入采访，以探讨他们对临床PRS的看法。我们通过有目的的抽样策略招募了30名年龄在35-50岁之间的生物库参与者，确保>75%的人自报为非洲人/非裔美国人或西班牙裔/拉丁裔，一半人说西班牙语。西班牙语或英语的半结构式访谈探讨了对PRS的态度，采用的障碍和沟通偏好。数据分析采用归纳专题分析方法。临床PRS的感知效用集中在个人健康益处的潜力上，大多数参与者表示，高风险结果将促使医生咨询和健康行为改变。参与者很少关注PRS对非欧洲人群的预测能力有限。接受减贫战略测试和采纳减贫战略相关建议的障碍包括社会经济因素、保险状况、种族、族裔、语言和对减贫战略的理解不足。参与者倾向于由他们的医生亲自披露PRS结果。研究结果提供了有价值的洞察不同的患者的态度和潜在的障碍，临床PRS，指导未来的研究和以患者为中心的临床实施。
As polygenic risk scores (PRS) emerge as promising tools to inform clinical care, there is a pressing need for patient-centered evidence to guide their implementation, particularly in diverse populations. Here, we conducted in-depth interviews of diverse Spanish- and English-speaking patients to explore their perspectives on clinical PRS. We enrolled 30 biobank participants aged 35–50 years through a purposive sampling strategy, ensuring that >75% self-reported as African/African American or Hispanic/Latinx and half were Spanish-speaking. Semistructured interviews in Spanish or English explored attitudes toward PRS, barriers to adoption, and communication preferences. Data were analyzed using an inductive thematic analysis approach. Perceived utility of clinical PRS focused on the potential for personal health benefits, and most participants stated that high-risk results would prompt physician consultations and health behavior changes. There was little concern among participants about the limited predictive power of PRS for non-European populations. Barriers to uptake of PRS testing and adoption of PRS-related recommendations included socioeconomic factors, insurance status, race, ethnicity, language, and inadequate understanding of PRS. Participants favored in-person PRS result disclosure by their physician. Findings provide valuable insight into diverse patients’ attitudes and potential barriers related to clinical PRS, guiding future research and patient-centered clinical implementation.
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DOI：
10.1038/s41436-018-0341-9
发表时间：
2019-06
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
Lewis KL;Heidlebaugh AR;Epps S;Han PKJ;Fishler KP;Klein WMP;Miller IM;Ng D;Hepler C;Biesecker BB;Biesecker LG
通讯作者：
Biesecker LG
影响因子：
24
作者：
Landry, Latrice G.;Rehm, Heidi L.
通讯作者：
Rehm, Heidi L.
影响因子：
82.9
作者：
Adeyemo, Adebowale;Balaconis, Mary K.;Zhou, Alicia
通讯作者：
Zhou, Alicia
在不同人群中实施基因组筛查。
影响因子：
12.3
作者：
Abul-Husn NS;Soper ER;Braganza GT;Rodriguez JE;Zeid N;Cullina S;Bobo D;Moscati A;Merkelson A;Loos RJF;Cho JH;Belbin GM;Suckiel SA;Kenny EE
通讯作者：
Kenny EE
影响因子：
1.7
作者：
Guest, Greg;Bunce, Arwen;Johnson, Laura
通讯作者：
Johnson, Laura