Inhibition of adrenocorticotropic hormone secretion in the rat by immunoneutralization of corticotropin-releasing factor.
Inhibition of adrenocorticotropic hormone secretion in the rat by immunoneutralization of corticotropin-releasing factor.
复制标题
通过促肾上腺皮质激素释放因子的免疫中和抑制大鼠促肾上腺皮质激素的分泌。
DOI：
10.1126/science.6289439
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Vale,W
中科院分区：
文献类型：
--
作者：
Rivier,C;Rivier,J;Vale,W
静脉注射兔抗血清羊促肾上腺皮质激素释放因子（CRF）显着减少CRF诱导的血浆促肾上腺皮质激素（ACTH）的上升在完整的非应激成年雄性大鼠，而阻断75%以上的ACTH释放大鼠暴露于乙醚的压力。此外，CRF抗血清显着降低肾上腺切除动物的ACTH水平。这些结果表明，内源性CRF在调节ACTH分泌中起生理作用。
Intravenous administration of rabbit antiserum to ovine corticotropin-releasing factor (CRF) markedly reduced the CRF-induced rise of plasma adrenocorticotropic hormone (ACTH) in intact nonstressed adult male rats while blocking more than 75 percent of the ACTH release observed in rats exposed to ether stress. Furthermore, antiserum to CRF significantly lowered ACTH levels in adrenalectomized animals. These results suggest that endogenous CRF plays a physiological role in regulating ACTH secretion.