Mechanisms of desmosome assembly and disassembly
Mechanisms of desmosome assembly and disassembly
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DOI：
10.1046/j.1365-2230.2002.01116.x
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发表时间：
2002-11-01
影响因子：
4.1
通讯作者：
Kitajima, Y
中科院分区：
文献类型：
--
作者：
Kitajima, Y
在皮肤中，桥粒构成相邻角质形成细胞之间的关键黏附复合物，有助于维持完整的表皮。然而，单个角质形成细胞需要迁移和分化，因此桥粒必须具有固有的动态组装和拆卸能力。这篇综述强调了参与桥粒形成和周转的不同结构连接成分的作用，以及可能涉及桥粒稳态的信号过程和途径。从人类遗传和获得性起泡性皮肤病以及动物模型和基础细胞生物学研究中，可以发现桥粒组装和拆卸的复杂本质。本文综述了这些发现对理解桥粒动力学的关键意义。
In skin, desmosomes constitute critical adhesion complexes between adjacent keratinocytes that help maintain an intact epidermis. However, individual keratinocytes need to migrate and differentiate and therefore desmosomes must have an inherent dynamic capacity to assemble and disassemble. This review highlights the role of the different structural junctional components involved in desmosome formation and turnover, as well as the possible signalling processes and pathways that may be implicated in desmosome homeostasis. Clues to the intricate nature of desmosome assembly and disassembly have been derived from human inherited and acquired blistering skin diseases as well as animal models and basic cell biology studies. The key implications for understanding desmosome dynamics from these findings are summarized in this review.