The origin of osteoclasts: evidence, clinical implications and investigative challenges of an extra-skeletal source.
The origin of osteoclasts: evidence, clinical implications and investigative challenges of an extra-skeletal source.
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破骨细胞的起源：骨骼外来源的证据、临床意义和研究挑战。
DOI：
10.1111/j.1600-0714.1983.tb00337.x
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
MarksJr,SC
中科院分区：
文献类型：
--
作者：
MarksJr,SC
最近的证据，破骨细胞和破骨细胞的起源的历史记录的extraskalloy起源的严格审查。综述了单核前体破骨细胞的结构、功能和发育，骨吸收的局部调节以及骨形成与前吸收的耦合，作为讨论溶骨性骨病管理的临床意义的背景。破骨细胞和巨噬细胞作为吞噬细胞的作用进行了比较和对比，并审查了最近的证据，巨噬细胞的异质性，从网站特定的单核细胞前体。巨噬细胞生物学的这些最新发展的影响外推到破骨细胞和存在的特定位点，extrasketosteoclast前体提出。最后，在这些角度固有的调查挑战进行了讨论。
Recent evidence for an extraskeletal origin of osteoclasts and the historical record of the genesis of osteoclasts are examined critically. Reviews of the structure, function and development of osteoclasts from mononuclear precursors, the local regulation of bone resorption and the coupling of bone formation to preceding resorption are presented as a background for discussing the clinical implications for management of osteolytic bone diseases. The roles of osteoclasts and macrophages as phagocytes are compared and contrasted, and recent evidence for macrophage heterogeneity resulting from site‐specific monoblastic precursors is reviewed. The implications of these recent developments in macrophage biology are extrapolated to osteoclasts and the existence of site‐specific, extraskeletal tsteoclast precursors is proposed. Finally, the investigative challenges inherent in these perspectives are discussed.