Microbial and viral pathogens in colorectal cancer
Microbial and viral pathogens in colorectal cancer
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DOI：
10.1016/s1470-2045(10)70186-8
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发表时间：
2011-05-01
期刊：
影响因子：
51.1
通讯作者：
Winter, Desmond C.
中科院分区：
文献类型：
--
作者：
Collins, Danielle;Hogan, Aisling M.;Winter, Desmond C.
结直肠癌的异质性和散发性导致了许多与其病因有关的流行病学研究。随着我们对结直肠癌潜在分子过程的理解的发展，微生物上皮相互作用作为致癌触发的概念可能为结直肠癌的发病机制提供一个可信的假说。与其他胃肠道癌症(胃癌、粘膜相关淋巴组织淋巴瘤)相比，微生物感染(细菌和病毒)与结直肠癌之间的直接因果关系尚未确定。研究支持这些微生物参与肿瘤的发生，然而，在结直肠癌中，缺乏临床数据。在这里，我们讨论目前的证据(体外和临床研究)，并集中在细菌和病毒病原体作为结直肠癌病因的推定作用。
The heterogenetic and sporadic nature of colorectal cancer has led to many epidemiological associations with causes of this disease. As our understanding of the underlying molecular processes in colorectal-cancer develops, the concept of microbial epithelial interactions as an oncogenic trigger might provide a plausible hypothesis for the pathogenesis of colorectal cancer. By contrast with other cancers of the gastrointestinal tract (gastric carcinoma, mucosa-associated lymphoid-tissue lymphoma), a direct causal link between microbial infection (bacteria and viruses) and colorectal carcinoma has not been established. Studies support the involvement of these organisms in oncogenesis, however, in colorectal cancer, clinical data are lacking. Here, we discuss current evidence (both in vitro and clinical studies), and focus on a putative role for bacterial and viral pathogens as a cause of colorectal cancer.