Simultaneous Tc-99m/I-123 dual-radionuclide myocardial perfusion/innervation imaging using Siemens IQ-SPECT with SMARTZOOM collimator.
Simultaneous Tc-99m/I-123 dual-radionuclide myocardial perfusion/innervation imaging using Siemens IQ-SPECT with SMARTZOOM collimator.
复制标题
使用带有 SMARTZOOM 准直器的西门子 IQ-SPECT 进行同步 Tc-99m/I-123 双放射性核素心肌灌注/神经支配成像。
DOI：
10.1088/0031-9155/59/11/2813
复制
发表时间：
2014
影响因子：
3.5
通讯作者：
Frey,EricC
中科院分区：
文献类型：
--
作者：
Du,Yong;Bhattacharya,Manojeet;Frey,EricC
同时双放射性核素心肌灌注/神经支配SPECT成像可以提供有关瘢痕组织和失神经支配区域之间不匹配的重要信息。为心脏成像开发的Siemens IQ-SPECT系统使用多焦点SMARTZOOM准直器，与典型的平行孔低能高分辨率准直器相比，可实现心脏区域的四倍灵敏度，但没有传统会聚束准直器可能导致的数据截断。增加的灵敏度允许更短的图像采集时间或减少的患者剂量，使IQ-SPECT成为同时双放射性核素SPECT的理想选择，其中需要减少给药活性以减少患者辐射暴露。然而，在双核素成像中，串扰是影响图像质量的主要因素。在这项工作中，我们开发了一种基于模型的方法，可以估计和补偿的串扰IQ-SPECT数据。串扰模型考虑了对象和准直器-检测器系统中的相互作用。使用有效源散射估计技术（ESSE），以前开发的平行孔准直器模型散射在对象中的散射建模。在IQ-SPECT投影仪中对几何准直器-探测器响应进行了分析建模。然后在迭代重建过程中补偿估计的串扰。新的方法进行了验证，从Monte Carlo模拟和物理体模实验的数据。结果表明，估算的串扰与仿真和实测结果吻合较好。在基于模型的补偿后，来自同时双放射性核素采集的图像在质量上与来自没有串扰污染的单放射性核素采集的图像相似。所提出的基于模型的方法可用于改善使用IQ-SPECT采集的同时双放射性核素图像。这项工作还表明，ESSE散射建模可以应用于非平行光束投影几何形状。
Simultaneous dual-radionuclide myocardial perfusion/innervation SPECT imaging can provide important information about the mismatch between scar tissue and denervated regions. The Siemens IQ-SPECT system developed for cardiac imaging uses a multifocal SMARTZOOM collimator to achieve a four-fold sensitivity for the cardiac region, compared to a typical parallel-hole low-energy high-resolution collimator, but without the data truncation that can result with conventional converging-beam collimators. The increased sensitivity allows shorter image acquisition times or reduced patient dose, making IQ-SPECT ideal for simultaneous dual-radionuclide SPECT, where reduced administrated activity is desirable in order to reduce patient radiation exposure. However, crosstalk is a major factor affecting the image quality in dual-radionuclide imaging. In this work we developed a model-based method that can estimate and compensate for the crosstalk in IQ-SPECT data. The crosstalk model takes into account interactions in the object and collimator-detector system. Scatter in the object was modeled using the effective source scatter estimation technique (ESSE), previously developed to model scatter with parallel-hole collimators. The geometric collimator-detector response was analytically modeled in the IQ-SPECT projector. The estimated crosstalk was then compensated for in an iterative reconstruction process. The new method was validated with data from both Monte Carlo simulations and physical phantom experiments. The results showed that the estimated crosstalk was in good agreement with simulated and measured results. After model-based compensation the images from simultaneous dual-radionuclide acquisitions were similar in quality to those from single-radionuclide acquisitions that did not have crosstalk contamination. The proposed model-based method can be used to improve simultaneous dual-radionuclide images acquired using IQ-SPECT. This work also demonstrates that ESSE scatter modeling can be applied to non-parallel-beam projection geometries.