Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory
Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory
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DOI：
10.1073/pnas.0607822103
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发表时间：
2006-10-31
影响因子：
11.1
通讯作者：
Abe, Kazuho
中科院分区：
文献类型：
--
作者：
Maher, Pamela;Akaishi, Tatsuhiro;Abe, Kazuho
激活神经营养因子使用的信号通路的小分子可用于治疗CNS疾病。在这里，我们表明，类黄酮非瑟酮激活ERK和诱导cAMP反应元件结合蛋白（CREB）在大鼠海马脑片磷酸化，促进大鼠海马脑片的长时程增强，并增强小鼠的物体识别。总之，这些数据表明，天然产物非瑟酮可以促进长期记忆，因此它可能有助于治疗记忆障碍患者。
Small molecules that activate signaling pathways used by neurotrophic factors could be useful for treating CNS disorders. Here we show that the flavonoid fisetin activates ERK and induces cAMP response element-binding protein (CREB) phosphorylation in rat hippocampal slices, facilitates long-term potentiation in rat hippocampal slices, and enhances object recognition in mice. Together, these data demonstrate that the natural product fisetin can facilitate long-term memory, and therefore it may be useful for treating patients with memory disorders.