Continuation/maintenance treatment with nortriptyline versus combined nortriptyline and ECT in late-life psychotic depression: a two-year randomized study.
Continuation/maintenance treatment with nortriptyline versus combined nortriptyline and ECT in late-life psychotic depression: a two-year randomized study.
复制标题
去甲替林继续/维持治疗与去甲替林联合 ECT 治疗晚年精神病性抑郁症的比较：一项为期两年的随机研究。
DOI：
10.1097/jgp.0b013e318170a6fa
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
R. Catalán
中科院分区：
文献类型：
--
作者：
V. Navarro;C. Gastó;X. Torres;G. Masana;R. Penadés;J. Guarch;M. Vázquez;Montserrat Serra;N. Pujol;L. Pintor;R. Catalán
客观的
OBJECTIVE
The identification of effective continuation and maintenance strategies for elderly patients with psychotic depression is a critical issue that has not been fully explored. The aim of this study was to assess the tolerability and efficacy of continuation/maintenance electroconvulsive therapy (ECT) in elderly patients with psychotic depression after acute ECT remission.
METHODS
The authors used a longitudinal, randomized, single-blind design to compare by survival analysis the 2-year outcome of two subgroups of elderly patients with psychotic unipolar depression who were ECT (plus nortriptyline) remitters. One group was treated with a continuation/maintenance nortriptyline regimen (N = 17) and the other with combined continuation/maintenance ECT plus nortriptyline (N = 16).
RESULTS
Over 2 years of treatment in elderly, psychotic, unipolar depressed ECT (plus nortriptyline) remitters, the mean survival time was significantly longer in the combined ECT plus nortriptyline subgroup than in the nortriptyline subgroup. No differences were observed between treatments with regard to tolerability.
CONCLUSIONS
This study supports the judicious use of combined continuation/maintenance ECT and antidepressant treatment in elderly patients with psychotic unipolar depression who are ECT remitters.
影响因子：
158.5
作者：
SACKEIM, HA;PRUDIC, J;SETTEMBRINO, JM
通讯作者：
SETTEMBRINO, JM
影响因子：
--
作者：
Kellner, Charles H.;Knapp, Rebecca G.;Fink, Max
通讯作者：
Fink, Max