Reactive oxygen species-sensitive thioketal-linked mesoporous silica nanoparticles as drug carrier for effective antibacterial activity
Reactive oxygen species-sensitive thioketal-linked mesoporous silica nanoparticles as drug carrier for effective antibacterial activity
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活性氧敏感的硫缩酮连接的介孔二氧化硅纳米粒子作为有效抗菌活性的药物载体
DOI：
10.1016/j.matdes.2020.109021
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发表时间：
2020-10-01
影响因子：
8.4
通讯作者：
Chen, Shijie
中科院分区：
文献类型：
--
作者：
Li, Jinsong;Ding, Zhiyu;Chen, Shijie
介孔二氧化硅纳米粒子（MSNs）携带的看门人，是刺激响应广泛研究的控制药物在靶点的传递。在这项研究中，硫代缩酮（TK）功能化的甲氧基聚（乙二醇）（mPEG-TK）作为ROS响应性看门人被用来修饰MSN，并导致活性氧（ROS）响应性抗菌药物的传输。以万古霉素（货车）为抗菌药物，将其物理包埋于表面氨基功能化的微球表面。随后，表面固定mPEG-TK。经mPEG-TK表面修饰的货车负载N-MSNs（Van-mPEG-TK-MSNs）在生理环境中36 h内释放约21%的货车。随着H_2O_2浓度的增加，Van-mPEG-TK-MSNs释放货车Van的速率显著增加。当Van-mPEG-TK-MSNs在体内应用时，感染部位在14天后完全清除，并且组织没有感染。总体而言，上述结果表明Van-mPEG-TK-MSNs可以作为潜在的抗菌剂。该研究可拓宽微胶囊的应用范围，促进新型抗菌剂的开发。(c)2020由Elsevier Ltd.发布。这是CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
Mesoporous silica nanoparticles (MSNs) carrying gatekeepers that are stimuli-responsive are widely investigated for the controlled delivery of drug at target sites. In this study, thioketal (TK) functionalized methoxy poly(ethylene glycol) (mPEG-TK) as ROS-responsive gatekeeper is used to modify MSNs and leads to a reactive oxygen species (ROS)-responsive delivery for antibacterial drug. Vancomycin (Van) was taken as the antibacterial drug and then physically encapsulated into the surface amino functionalized MSNs (N-MSNs). Subsequently, mPEG-TK was surface immobilized. Van loaded N-MSNs with surface modification of mPEG-TK (Van-mPEG-TK-MSNs) presented approximately 21% release of Van in a physiological environment in 36 h. With H2O2 increasing in the medium, the release rate of Van from Van-mPEG-TK-MSNs was significantly up-regulated following gatekeepers' disintegration. When Van-mPEG-TK-MSNs was applied in vivo, the infected site was fully cleared after 14 days and the tissue was free of infection. On the whole, the mentioned results suggested that Van-mPEG-TK-MSNs could act as a potential antimicrobial. This study can broaden MSNs' applications and advance the development of novel antibacterial agents. (c) 2020 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).