An improved PID switching control strategy for type 1 diabetes.
An improved PID switching control strategy for type 1 diabetes.
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1型糖尿病改进的PID切换控制策略
DOI：
10.1109/iembs.2006.259541
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Seborg,DaleE
中科院分区：
文献类型：
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作者：
Marchetti,Gianni;Barolo,Massimiliano;Jovanovic,Lois;Zisser,Howard;Seborg,DaleE
为了使“人工胰腺”成为流动使用的现实，必须开发和验证实用的闭环控制策略。在本文中，提出了一种改进的血糖控制 PID 控制策略，并使用 Hovorka 等人的生理模型进行了严格的计算机评估。所提出的控制策略的主要特点是：1）在餐后和胰岛素推注后启动 PID 控制的切换策略； 2）新颖的时变设定点轨迹； 3）噪声和微分滤波器，以降低对传感器噪声的敏感度； 4）实用的控制器调整策略。模拟结果表明，所提出的控制策略优于现实条件下的替代方案，包括膳食挑战、不正确的碳水化合物膳食估计、胰岛素敏感性的变化和测量噪声。
In order for an "artificial pancreas" to become a reality for ambulatory use, a practical closed-loop control strategy must be developed and validated. In this paper, an improved PID control strategy for blood glucose control is proposed and critically evaluated in silico using a physiologic model of Hovorka et al. The key features of the proposed control strategy are: 1) a switching strategy for initiating PID control after a meal and insulin bolus; 2) a novel time-varying setpoint trajectory; 3) noise and derivative filters to reduce sensitivity to sensor noise; and 4) a practical controller tuning strategy. Simulation results demonstrate that proposed control strategy compares favorably to alternatives for realistic conditions that include meal challenges, incorrect carbohydrate meal estimates, changes in insulin sensitivity, and measurement noise.