Recombinant human migration inhibitory factor has adjuvant activity.
Recombinant human migration inhibitory factor has adjuvant activity.
复制标题
重组人迁移抑制因子具有佐剂活性。
DOI：
10.1073/pnas.89.17.8049
复制
发表时间：
1992
影响因子：
11.1
通讯作者：
David,JR
中科院分区：
文献类型：
--
作者：
Weiser,WY;Pozzi,LM;Titus,RG;David,JR
Recombinant human migration inhibitory factor (MIF), isolated through functional expression cloning in COS-1 cells, up-regulates expression of genes encoding HLA-DR and interleukin 1 beta (IL-1 beta) and elaboration of IL-1 beta by human monocyte-derived macrophages. Administration of soluble bovine serum albumin or human immunodeficiency virus 120-kDa glycoprotein (HIV gp120) to mice in the presence of recombinant MIF together with incomplete Freund's adjuvant induced a strong T-cell proliferative response comparable to that of complete Freund's adjuvant. Recombinant MIF also increased antibody production, especially of IgG1 and IgM, in mice. Taken together, these results indicate that recombinant MIF may be useful as an adjuvant in the development of vaccines.
