Interaction of Viruses with the Insect Intestine
Interaction of Viruses with the Insect Intestine
复制标题
病毒与昆虫肠道的相互作用
DOI：
10.1146/annurev-virology-091919-100543
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发表时间：
2021-01-01
期刊：
影响因子：
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通讯作者：
Cheng, Gong
中科院分区：
文献类型：
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作者：
Ma, Enhao;Zhu, Yibin;Cheng, Gong
在自然界中，昆虫面临着许多外源病毒感染的持续威胁，它们的肠道是主要的进入口。昆虫可以在吸血昆虫吸血或食草昆虫吸食树液和树叶时通过口服获得这些病毒。然而，昆虫肠道形成了几种物理和免疫屏障来防御病毒入侵，包括细胞固有的抗病毒免疫、围食基质和粘蛋白层以及局部共生微生物。感染能否在肠道中成功建立取决于病毒与这些屏障之间复杂的相互作用。本文综述了近年来昆虫肠道病毒相互作用的研究进展，其中营养状况、共生微生物的动力学以及病毒编码组分等因素直接或间接地对病毒入侵肠道起着复杂的调控作用。
In nature, insects face a constant threat of infection by numerous exogeneous viruses, and their intestinal tracts are the predominant ports of entry. Insects can acquire these viruses orally during either blood feeding by hematophagous insects or sap sucking and foliage feeding by insect herbivores. However, the insect intestinal tract forms several physical and immunological barriers to defend against viral invasion, including cell intrinsic antiviral immunity, the peritrophic matrix and the mucin layer, and local symbiotic microorganisms. Whether an infection can be successfully established in the intestinal tract depends on the complex interactions between viruses and those barriers. In this review, we summarize recent progress on virus-intestinal tract interplay in insects, in which various underlying mechanisms derived from nutritional status, dynamics of symbiotic microorganisms, and virus-encoded components play intricate roles in the regulation of virus invasion in the intestinal tract, either directly or indirectly.