Recreating the biological pacemaker.
Recreating the biological pacemaker.
复制标题
重建生物起搏器。
DOI：
10.1002/ar.a.20073
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Cohen,IraS
中科院分区：
文献类型：
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作者：
Rosen,MichaelR;Robinson,RichardB;Brink,Peter;Cohen,IraS
近年来，一些研究小组报告了开发生物起搏器的各种策略，其最终功能是补充/替代电子起搏器。策略包括使用裸质粒或病毒载体的基因治疗以及使用成人间充质干细胞（hMSC）和人胚胎干细胞的细胞治疗。本文回顾了各种方法并总结了我们自己的研究，其中通过病毒载体或在 hMSC 平台中施用起搏器基因 HCN2，以在完整的犬心脏中产生起搏器功能。 © 2004 Wiley-Liss, Inc.
In recent years, several groups have reported a variety of strategies for developing biological pacemakers whose ultimate function would be to supplement/replace electronic pacemakers. Strategies have included gene therapy using naked plasmids or viral vectors and cell therapy for which both adult human mesenchymal stem cells (hMSCs) and human embryonic stem cells have been employed. This article reviews the various approaches and summarizes our own research in which the pacemaker gene, HCN2, is administered via viral vector or in an hMSC platform to produce pacemaker function in the intact canine heart. © 2004 Wiley‐Liss, Inc.