Weighing the Evidence in Peters' Rule: Does Neuronal Morphology Predict Connectivity?
Weighing the Evidence in Peters' Rule: Does Neuronal Morphology Predict Connectivity?
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DOI：
10.1016/j.tins.2016.11.007
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发表时间：
2017-02
影响因子：
15.9
通讯作者：
Ascoli GA
中科院分区：
文献类型：
--
作者：
Rees CL;Moradi K;Ascoli GA
尽管网络连接的重要性越来越被认识到，但相对于神经元形态的常规表征，识别突触仍然具有挑战性。因此，研究人员经常使用轴突-树突配对作为潜在连接的代理。这种假定的对等，通常被称为彼得斯规则，最近在多个层面和尺度上进行了研究，引发了关于其有效性的激烈辩论。我们的批判性文献综述确定了三个概念上不同但经常混淆的应用：推断神经元类型电路，预测单个细胞之间的突触接触，以及估计神经元对内的突触数量。矛盾的是，在最初提出的细胞类型水平上，彼得斯的规则在很大程度上仍未经检验。利用Hippocampome.org，我们验证并完善了轴突-树突配位与突触回路之间的关系，澄清了对现有和未来数据的解释。
Although the importance of network connectivity is increasingly recognized, identifying synapses remains challenging relative to the routine characterization of neuronal morphology. Thus, researchers frequently employ axon–dendrite colocations as proxies of potential connections. This putative equivalence, commonly referred to as Peters’ rule, has been recently studied at multiple levels and scales, fueling passionate debates regarding its validity. Our critical literature review identifies three conceptually distinct but often confused applications: inferring neuron type circuitry, predicting synaptic contacts among individual cells, and estimating synapse numbers within neuron pairs. Paradoxically, at the originally proposed cell-type level, Peters’ rule remains largely untested. Leveraging Hippocampome.org, we validate and refine the relationship between axonal–dendritic colocations and synaptic circuits, clarifying the interpretation of existing and forthcoming data.