Electrically evoked auditory nerve responses in the cochlea with normal outer hair cells.
Electrically evoked auditory nerve responses in the cochlea with normal outer hair cells.
复制标题
电诱发耳蜗中具有正常外毛细胞的听觉神经反应。
DOI：
10.1016/s1672-2930(09)50017-7
复制
发表时间：
2009
影响因子：
1.9
通讯作者：
Nuttall,AlfredL
中科院分区：
文献类型：
--
作者：
Ren,Tianying;Guo,Menghe;He,Wenxuan;Miller,JosefM;Nuttall,AlfredL
随着混合型人工耳蜗越来越多地用于恢复听力残障患者的听力，了解具有功能毛细胞的耳蜗的电诱发反应是很重要的。为了验证正弦波电流耳蜗外电刺激（EES）可以引起正常频率选择性听神经反应的假设，本研究对耳蜗外电刺激诱发的复合动作电位（ECAP）进行了研究。短暂的正弦电流，通过圆窗电极传递，用来唤起ECAP。观察到ECAP波形与声诱发CAP（ACAP）相同，只是潜伏期更短。acap和ecap的输入/输出和强度/潜伏期功能也相似。ACAP和ECAP的最大声掩蔽都发生在探针频率附近。由于CAP的屏蔽调谐曲线反映了神经兴奋的频率选择性，这些数据表明听神经的高度特异性激活，这将导致高度的频率选择性。这种频率选择性可能是由电刺激外毛细胞引起的耳蜗行波引起的。
As hybrid cochlear implant devices are increasingly used for restoring hearing in patients with residual hearing, it is important to understand electrically evoked responses in cochleae having functional hair cells. To test the hypothesis that extracochlear electrical stimulation (EES) from sinusoidal current can provoke an auditory nerve response with normal frequency selectivity, the EES–evoked compound action potential (ECAP) was investigated in this study. Brief sinusoidal electrical currents, delivered via a round window electrode, were used to evoke ECAP. The ECAP waveform was observed to be the same as the acoustically evoked CAP(ACAP), except for a shorter latency. The input/output and intensity/latency functions of ACAPs and ECAPs were also similar. The maximum acoustic masking for both ACAP and ECAP occurred near probe frequencies. Since the masked tuning curve of a CAP reflects the frequency selectivity of neural excitation, these data demonstrate a highly specific activation of the auditory nerve, which would result in high degree of frequency selectivity. This frequency selectivity likely results from the cochlear traveling wave caused by electrically stimulated outer hair cells.