Effects of cold exposure on insulin and glucagon secretion in sheep.
Effects of cold exposure on insulin and glucagon secretion in sheep.
复制标题
寒冷暴露对绵羊胰岛素和胰高血糖素分泌的影响。
DOI：
10.1210/endo-111-6-2070
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发表时间：
1982
期刊：
影响因子：
4.8
通讯作者：
T. Weekes
中科院分区：
文献类型：
--
作者：
Y. Sasaki;Hideyuki Takahashi;H. Aso;A. Ohneda;T. Weekes
用5只成年绵羊研究了冷暴露对胰岛素和胰高血糖素分泌的影响。在温暖的环境中和冷暴露（0 ℃）后4-19天研究内分泌反应。与室温下的水平相比，基础血浆葡萄糖水平在冷暴露期间升高，但血浆胰岛素和胰高血糖素的基础水平不变。冷暴露显著降低了早期胰岛素对静脉输注葡萄糖的反应。在葡萄糖输注期间，血浆葡萄糖和胰高血糖素水平不受冷暴露的影响。静脉注射胰岛素（0.2 U/kg BW）后，血浆葡萄糖的下降幅度在冷暴露期间大于室温。丁酸注射液（0.625 mmol/kg，iv）导致在寒冷环境中胰岛素和胰高血糖素的分泌显著低于在温暖环境中。胰高血糖素对精氨酸输注（0.5 g/kg，30 min，iv）的反应通过冷暴露升高，而胰岛素对精氨酸的反应倾向于降低。普萘洛尔输注（20 μ g/kg . min，iv）在冷环境中引起胰岛素分泌的轻微抑制，但在冷或热环境中均不影响胰高血糖素水平。酚妥拉明输注（20微克/公斤。min，iv）抑制胰高血糖素分泌，特别是在寒冷的环境中，并且在寒冷中引起显著更大的胰岛素分泌刺激。它的结论是，冷暴露不足以导致体温降低胰岛素分泌的各种刺激。寒冷对胰高血糖素分泌的影响取决于所用的刺激剂。
The effectiveness of cold exposure on the secretion of insulin and glucagon were examined using five adult sheep. Endocrine responses were studied in a warm environment and after cold exposure (0 C) from 4-19 days. Compared to levels at room temperature, basal plasma glucose levels were elevated during cold exposure, but basal levels of plasma insulin and glucagon were unchanged. Cold exposure significantly decreased the early insulin response to a primed iv infusion of glucose. Plasma glucose and glucagon levels during glucose infusion were unaffected by cold exposure. The decrease in plasma glucose after iv insulin injection (0.2 U/kg BW) was greater during cold exposure than at room temperature. Butyrate injection (0.625 mmol/kg, iv) resulted in a significantly lower secretion of both insulin and glucagon in the cold than in the warm environment. The glucagon response to arginine infusion (0.5 g/kg over 30 min, iv) was elevated by cold exposure, whereas the insulin response to arginine tended to be reduced. Propranolol infusion (20 micrograms/kg . min, iv) caused a slight inhibition of insulin secretion in the cold environment, but did not affect glucagon levels in either the cold or warm environment. Phentolamine infusion (20 micrograms/kg . min, iv) inhibited glucagon secretion, particularly in the cold environment, and caused a markedly greater stimulation of insulin secretion in the cold. It is concluded that cold exposure insufficient to cause hypothermia decreases insulin secretion in response to a variety of stimuli. Effects of cold on glucagon secretion depend upon the stimulating agent used.