Specialized regulatory T cells control venous blood clot resolution through SPARC
Specialized regulatory T cells control venous blood clot resolution through SPARC
复制标题
DOI：
10.1182/blood.2020005407
复制
发表时间：
2021-03-18
期刊：
影响因子：
20.3
通讯作者：
Becker, Christian
中科院分区：
文献类型：
--
作者：
Shahneh, Fatemeh;Grill, Alexandra;Becker, Christian
涉及血凝块再吸收的细胞和机制仅部分已知。我们发现，调节性T细胞（T细胞）积累在静脉血凝块和调节血栓溶解通过控制招聘，分化和基质金属蛋白酶（MMP）的单核细胞的活性。我们描述了一个凝块Treg群体，形成了富含基质细胞酸和半胱氨酸的蛋白质MMP（分泌的蛋白质酸性和富含半胱氨酸），并表明MMP增强单核细胞MMP活性，而MMP（+）TcR对血凝块吸收至关重要。通过比较不同的治疗时间，我们定义了加速凝块再吸收的Treg扩增的治疗窗口。
The cells and mechanisms involved in blood clot resorption are only partially known. We show that regulatory T cells (Tregs) accumulate in venous blood clots and regulate thrombolysis by controlling the recruitment, differentiation and matrix metalloproteinase (MMP) activity of monocytes. We describe a clot Treg population that forms the matricellular acid- and cysteine-rich protein SPARC (secreted protein acidic and rich in cysteine) and show that SPARC enhances monocyte MMP activity and that SPARC(+) Tregs are crucial for blood clot resorption. By comparing different treatment times, we define a therapeutic window of Treg expansion that accelerates clot resorption.