Mechanism of resistance to steroids: glucocorticoid receptor defect in lymphoma cells.
Mechanism of resistance to steroids: glucocorticoid receptor defect in lymphoma cells.
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类固醇抵抗机制：淋巴瘤细胞中糖皮质激素受体缺陷。
DOI：
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
G. Tomkins
中科院分区：
文献类型：
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作者：
W. Rosenau;J. Baxter;G. Rousseau;G. Tomkins
糖皮质激素会引起正常和肿瘤性淋巴细胞1,2的细胞溶解，这种反应是使用这些化合物治疗肿瘤性、自身免疫性和其他淋巴系统疾病的基础。不幸的是，在治疗过程中常常会产生对类固醇的抵抗力，导致激素治疗无效。
GLUCOCORTICOIDS cause cytolysis of normal and neoplastic lymphoid cells1,2—a reaction which is one basis for the use of these compounds in the therapy of neoplastic, autoimmune and other diseases of the lymphoid system. Unfortunately, resistance to steroids often develops during treatment, rendering the hormones therapeutically ineffective.