Alkalinization of amide local anaesthetics by addition of 1% sodium bicarbonate solution
Alkalinization of amide local anaesthetics by addition of 1% sodium bicarbonate solution
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DOI：
10.1046/j.1365-2346.2000.00596.x
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发表时间：
2000-01-01
影响因子：
3.6
通讯作者：
Allen, JG
中科院分区：
文献类型：
--
作者：
Milner, QJW;Guard, BC;Allen, JG
有许多方法可以提高局部麻醉剂溶液的pH值。最常见的情况是，根据局部麻醉药物的不同，需要添加不同数量的碳酸氢钠溶液。用碳酸氢钠(1%)与六种常用的局麻药溶液中的pH值进行滴定。这组局部麻醉剂的pH和加入的碳酸氢钠溶液的体积的滴定曲线是显示的。这项研究表明，1毫升1%的碳酸氢钠溶液可以用来使这一范围的局部麻醉剂碱化，而不会有沉淀的风险。我们还得出结论，罗比卡因(浓度为0.75%和1.0%)不适合碱化，因为它在pH为6.0时沉淀。
A number of methods exist by which the pH of local anaesthetic solutions may be increased. Most commonly, these require the addition of differing amounts of sodium bicarbonate solution according to the local anaesthetic drugs. Sodium bicarbonate (1%) was titrated against pH in six commonly used local anaesthetic solutions. Titration curves of pH and volume of sodium bicarbonate solution added are shown for this group of local anaesthetics. This study demonstrates that 1 mL of 1% sodium bicarbonate solution may be used to alkalinize this range of local anaesthetics without the risk of precipitation. We also conclude that Ropivacaine (at concentration 0.75% and 1.0%), is unsuitable for alkalinization since it precipitates at a pH of 6.0.