Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder
Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder
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DOI：
10.1002/cbf.940
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发表时间：
2002-06-01
影响因子：
3.6
通讯作者：
Cinkilinc, N
中科院分区：
文献类型：
--
作者：
Kuloglu, M;Ustundag, B;Cinkilinc, N
最近来自几份报告的数据表明，自由基参与了许多人类病理学的发病机制，包括精神分裂症、双相情感障碍等神经精神疾病。在本研究中，我们的目的是确定和评估被诊断患有以下疾病的患者中丙二醛（MDA）（脂质过氧化产物）和抗氧化酶（超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的活性水平精神分裂症（n = 25）和双相情感障碍（n = 23）由20名健康受试者组成，与对照组相比，精神分裂症和双相情感障碍患者的NIDA水平显着升高，而双相情感障碍组的SOD活性水平显着高于对照组。与对照组相比，双相情感障碍患者的脂质过氧化产物和抗氧化酶（SOD 和 GSH-Px）活性水平存在显着差异，这使我们相信这些差异与这些疾病的病因学异质性有关。版权所有 (C) 2002 John Wiley Sons, Ltd.。
Recent data from several reports indicate that free radicals are involved in aetiopathogenesis of many human pathologies including neuropsychiatric disorders such as schizophrenia, bipolar disorder etc. In the present study, we aimed at determining and evaluating levels of malondialdehyde (MDA), a product of lipid peroxidation, and antioxidant enzyme (superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity levels in patients diagnosed with schizophrenia (n=25) and bipolar disorder (n=23). The control group was composed of 20 healthy subjects. There was a significant increase in NIDA levels of patients with schizophrenia and bipolar disorder compared with controls. SOD and GSH-Px activity levels were significantly higher in the schizophrenic group compared with controls. SOD activity levels in bipolar the group were significantly higher than controls whereas there were no significant changes in GSH-Px activity levels in the bipolar group and controls. Significant differences between lipid peroxidation product and antioxidant enzyme (SOD and GSH-Px) activity levels in schizophrenic and bipolar disorder patients compared with controls leads us to believe that these differences are related to the heterogenities in aetiologies of these disorders. Copyright (C) 2002 John Wiley Sons, Ltd.