EBV glycoproteins: where are we now?
EBV glycoproteins: where are we now?
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DOI：
10.2217/fvl.15.80
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发表时间：
2015
期刊：
影响因子：
3.1
通讯作者：
Hutt-Fletcher LM
中科院分区：
文献类型：
--
作者：
Hutt-Fletcher LM
糖蛋白对于病毒进入、在宿主内和宿主之间传播至关重要，并且可以改变细胞的行为。许多病毒只携带少数几种，大多数存在于病毒体包膜中。EB病毒制造超过12个，提供了它如何殖民人类宿主的灵活性。有些细胞专门负责让病毒穿过细胞膜，进入细胞核，有些则帮助引导病毒返回到同一宿主或新宿主的下一个细胞。然而，其他人破坏宿主防御，帮助病毒持续一生，保持一种大多数被容忍的存在，并使EBV成为人类最常见的感染之一。
Glycoproteins are critical to virus entry, to spread within and between hosts and can modify the behavior of cells. Many viruses carry only a few, most found in the virion envelope. EBV makes more than 12, providing flexibility in how it colonizes its human host. Some are dedicated to getting the virus through the cell membrane and on toward the nucleus of the cell, some help guide the virus back out and on to the next cell in the same or a new host. Yet others undermine host defenses helping the virus persist for a lifetime, maintaining a presence that is mostly tolerated and serves to perpetuate EBV as one of the most common infections of man.