Effect of TACI signaling on humoral immunity and autoimmune diseases.
Effect of TACI signaling on humoral immunity and autoimmune diseases.
复制标题
TACI 信号传导对体液免疫和自身免疫性疾病的影响
DOI：
10.1155/2015/247426
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发表时间：
2015
影响因子：
4.1
通讯作者：
Tao J
中科院分区：
文献类型：
--
作者：
Zhang Y;Li J;Zhang YM;Zhang XM;Tao J
Transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) is one of the receptors of B cell activating factor of the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL). TACI is a regulator in the immune responses. TACI inhibits B cell expansion and promotes the differentiation and survival of plasma cells. The mechanisms underlying these effects probably involve changed expressions of some crucial molecules, such as B lymphocyte induced maturation protein-1 (Blimp-1) and inducible T-cell costimulator ligand (ICOSL) in B cells and/or plasma cells. However, abnormal TACI signaling may relate to autoimmune disorders. Common variable immune deficiency (CVID) patients with heterozygous mutations in TACI alleles increase susceptibility to autoimmune diseases. Taci −/− mice and BAFF transgenic mice both develop signs of human SLE. These findings that indicate inappropriate levels of TACI signaling may disrupt immune system balance, thereby promoting the development of autoimmune diseases. In this review, we summarize the basic characteristics of the TACI ligands BAFF and APRIL, and detail the research findings on the role of TACI in humoral immunity. We also discuss the possible mechanisms underlying the susceptibility of CVID patients with TACI mutations to autoimmune diseases and the role of TACI in the pathogenesis of SLE.
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DOI：
10.1084/jem.20130505
发表时间：
2014-01-13
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Goenka R;Matthews AH;Zhang B;O'Neill PJ;Scholz JL;Migone TS;Leonard WJ;Stohl W;Hershberg U;Cancro MP
通讯作者：
Cancro MP
影响因子：
30.8
作者：
Castigli, E;Wilson, SA;Geha, RS
通讯作者：
Geha, RS
影响因子：
32.4
作者：
Figgett, William A.;Fairfax, Kirsten;Mackay, Fabienne
通讯作者：
Mackay, Fabienne
影响因子：
4.9
作者：
Dillon SR;Harder B;Lewis KB;Moore MD;Liu H;Bukowski TR;Hamacher NB;Lantry MM;Maurer M;Krejsa CM;Ellsworth JL;Pederson S;Elkon KB;Wener MH;Dall'Era M;Gross JA
通讯作者：
Gross JA
TACI和BAFF-R介导B细胞中的同种型切换。
影响因子：
15.3
作者：
Castigli, E;Wilson, SA;Scott, S;Dedeoglu, F;Xu, SL;Lam, KP;Bram, RJ;Jabara, H;Geha, RS
通讯作者：
Geha, RS