Efficacy of Leuprolide Acetate 1-Month Depot for Central Precocious Puberty (CPP): Growth Outcomes During a Prospective, Longitudinal Study.
Efficacy of Leuprolide Acetate 1-Month Depot for Central Precocious Puberty (CPP): Growth Outcomes During a Prospective, Longitudinal Study.
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DOI：
10.1186/1687-9856-2011-7
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Chwalisz K
中科院分区：
文献类型：
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作者：
Lee PA;Neely EK;Fuqua J;Yang D;Larsen LM;Mattia-Goldberg C;Chwalisz K
促性腺激素释放激素类似物（GnRHa）是CPP的治疗选择。我们研究了接受醋酸亮丙瑞林1个月贮库型制剂治疗CPP的GnRHa初治受试者的生长情况。这项前瞻性、开放标签研究具有长期、观察性、随访期。入组了49名女性和6名男性。醋酸亮丙瑞林贮库型制剂每28天肌内给药一次。测量治疗期间和治疗后直至成年的身高和生长速度。在30的49名女性有成年身高（AH）的测量，29个目标高度（平均值= 163.8厘米）和27个预处理预测的成年身高（多环芳烃;平均值= 157.4厘米）。治疗后，平均年龄21.8岁[范围13.7-26.7岁]时的平均AH为162.5 cm，与基线PAH相比平均身高增加4.0 cm。AH时平均身高标准差评分为-0.1。使用醋酸亮丙瑞林1个月贮库型制剂治疗CPP对AH的生长速率和保存具有有益影响。ClinicalTrials.gov：NCT00660010
Gonadotropin-releasing hormone analogs (GnRHa) are the treatment of choice for CPP. We investigated growth in GnRHa-naïve subjects, treated with leuprolide acetate 1-month depot for CPP. This prospective, open-label study had a long-term, observational, follow-up period. Forty-nine females and 6 males were enrolled. Leuprolide acetate depot was administered intramuscularly every 28 days. Height and growth rate during and after treatment until adulthood were measured. Among 30 of 49 females having an adult height (AH) measurement, 29 had target heights available (mean = 163.8 cm) and 27 had pretreatment predicted adult heights (PAHs; mean = 157.4 cm). After treatment, the mean AH at mean age 21.8 years [range 13.7-26.7 years] was 162.5 cm, a mean height gain over baseline PAH of 4.0 cm. The mean height standard deviation score was -0.1 at AH. Treatment of CPP with leuprolide acetate 1-month depot had beneficial effects on growth rate and preservation of AH. ClinicalTrials.gov: NCT00660010